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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

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2022

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You, Hang
Mao, Xin
Wang, Chenyang
Huang, Gang
Li, Jun

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JoVE Journal of Visualized Experiments. JoVE. 2022(180), e63464. eISSN 1940-087X. Available under: doi: 10.3791/63464

Zusammenfassung

Renal allograft rejection limits the long-term survival of patients after renal transplantation. Rat orthotopic renal transplantation is an essential model to investigate the mechanism of renal allograft rejection in pre-clinical studies and could aid in the development of novel approaches to improve the long-term survival of renal allografts. Donor kidney implantation in rat orthotopic renal transplantation is commonly performed by end-to-side anastomosis to recipients' aorta and inferior vena cava. In this model, the donor's kidney was implanted using end-to-end anastomosis to the recipients' renal artery and renal vein. The donor's ureter was anastomosed to the recipient's bladder in an end-to-side 'tunnel' method. This model contributes to better healing of ureter-bladder anastomosis and increases the recipients' survival by avoiding interference with blood supply and venous reflux of the lower body. This model can be used to investigate the mechanisms of acute and chronic immune and pathologic rejection of renal allografts. Here, the study describes the detailed protocols of this orthotopic renal transplantation between rats.

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570 Biowissenschaften, Biologie

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ISO 690YOU, Hang, Xin MAO, Chenyang WANG, Gang HUANG, Marcus GRÖTTRUP, Jun LI, 2022. A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection. In: JoVE Journal of Visualized Experiments. JoVE. 2022(180), e63464. eISSN 1940-087X. Available under: doi: 10.3791/63464
BibTex
@article{You2022-02-02Ortho-56896,
  year={2022},
  doi={10.3791/63464},
  title={A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection},
  number={180},
  journal={JoVE Journal of Visualized Experiments},
  author={You, Hang and Mao, Xin and Wang, Chenyang and Huang, Gang and Gröttrup, Marcus and Li, Jun},
  note={Article Number: e63464}
}
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    <dcterms:abstract xml:lang="eng">Renal allograft rejection limits the long-term survival of patients after renal transplantation. Rat orthotopic renal transplantation is an essential model to investigate the mechanism of renal allograft rejection in pre-clinical studies and could aid in the development of novel approaches to improve the long-term survival of renal allografts. Donor kidney implantation in rat orthotopic renal transplantation is commonly performed by end-to-side anastomosis to recipients' aorta and inferior vena cava. In this model, the donor's kidney was implanted using end-to-end anastomosis to the recipients' renal artery and renal vein. The donor's ureter was anastomosed to the recipient's bladder in an end-to-side 'tunnel' method. This model contributes to better healing of ureter-bladder anastomosis and increases the recipients' survival by avoiding interference with blood supply and venous reflux of the lower body. This model can be used to investigate the mechanisms of acute and chronic immune and pathologic rejection of renal allografts. Here, the study describes the detailed protocols of this orthotopic renal transplantation between rats.</dcterms:abstract>
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