Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy
Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy
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Date
2019
Authors
Graepel, Rabea
ter Braak, Bas
Escher, Sylvia E.
Fisher, Ciarán
Gardner, Ian
Kamp, Hennicke
Kroese, Dinant
Moné, Martijn J.
Pastor, Manuel
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Journal article
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Current Opinion in Toxicology ; 15 (2019). - pp. 33-39. - ISSN 2468-2020
Abstract
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM) - based approaches for risk assessment. In this European research project experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and regulatory agencies work together. Using a series of custom designed case studies the EU-ToxRisk battery of NAMs is being evaluated to learn how to carry out safety assessment using NAMs. This review article provides an overview of the project, its aims and approach and the methodologies that are being used.
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Subject (DDC)
570 Biosciences, Biology
Keywords
Hazard assessment, Mechanism-based testing, in vitro, in silico, Repeated dose toxicity (RDT), Developmental and reproductive toxicity (DART)
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Review
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GRAEPEL, Rabea, Bas TER BRAAK, Sylvia E. ESCHER, Ciarán FISHER, Ian GARDNER, Hennicke KAMP, Dinant KROESE, Marcel LEIST, Martijn J. MONÉ, Manuel PASTOR, 2019. Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy. In: Current Opinion in Toxicology. 15, pp. 33-39. ISSN 2468-2020. Available under: doi: 10.1016/j.cotox.2019.03.005BibTex
@article{Graepel2019-03Parad-45776, year={2019}, doi={10.1016/j.cotox.2019.03.005}, title={Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy}, volume={15}, issn={2468-2020}, journal={Current Opinion in Toxicology}, pages={33--39}, author={Graepel, Rabea and ter Braak, Bas and Escher, Sylvia E. and Fisher, Ciarán and Gardner, Ian and Kamp, Hennicke and Kroese, Dinant and Leist, Marcel and Moné, Martijn J. and Pastor, Manuel} }
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