Publikation:

Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy

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Datum

2019

Autor:innen

Graepel, Rabea
ter Braak, Bas
Escher, Sylvia E.
Fisher, Ciarán
Gardner, Ian
Kamp, Hennicke
Kroese, Dinant
Moné, Martijn J.
Pastor, Manuel
et al.

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https://doi.org/10.1016/j.cotox.2019.03.005
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Biologie: Publikationen
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Published

Erschienen in

Current Opinion in Toxicology. 2019, 15, pp. 33-39. ISSN 2468-2020. Available under: doi: 10.1016/j.cotox.2019.03.005

Zusammenfassung

The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM) - based approaches for risk assessment. In this European research project experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and regulatory agencies work together. Using a series of custom designed case studies the EU-ToxRisk battery of NAMs is being evaluated to learn how to carry out safety assessment using NAMs. This review article provides an overview of the project, its aims and approach and the methodologies that are being used.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Hazard assessment, Mechanism-based testing, in vitro, in silico, Repeated dose toxicity (RDT), Developmental and reproductive toxicity (DART)

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ISO 690GRAEPEL, Rabea, Bas TER BRAAK, Sylvia E. ESCHER, Ciarán FISHER, Ian GARDNER, Hennicke KAMP, Dinant KROESE, Marcel LEIST, Martijn J. MONÉ, Manuel PASTOR, 2019. Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy. In: Current Opinion in Toxicology. 2019, 15, pp. 33-39. ISSN 2468-2020. Available under: doi: 10.1016/j.cotox.2019.03.005
BibTex
@article{Graepel2019-03Parad-45776,
  year={2019},
  doi={10.1016/j.cotox.2019.03.005},
  title={Paradigm Shift in Safety Assessment Using New Approach Methods : the EU-ToxRisk Strategy},
  volume={15},
  issn={2468-2020},
  journal={Current Opinion in Toxicology},
  pages={33--39},
  author={Graepel, Rabea and ter Braak, Bas and Escher, Sylvia E. and Fisher, Ciarán and Gardner, Ian and Kamp, Hennicke and Kroese, Dinant and Leist, Marcel and Moné, Martijn J. and Pastor, Manuel}
}
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