Publikation:

Scaffolding microdomains and beyond : the function of reggie/flotillin proteins

Vorschaubild

Dateien

115_Scaffolding_microdomains_and_beyond.pdf
115_Scaffolding_microdomains_and_beyond.pdfGröße: 642.09 KBDownloads: 1003

Datum

2005

Autor:innen

Langhorst, Matthias F.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-39304
DOI (zitierfähiger Link)
https://doi.org/10.1007/s00018-005-5166-4
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Attribution-NonCommercial-NoDerivs 2.0 Generic

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Cellular and Molecular Life Science. 2005, 62(19-20), pp. 2228-2240. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-005-5166-4

Zusammenfassung

Reggie/flotillin proteins are considered to be components of lipid rafts and are commonly used as marker proteins for lipid microdomains. Yet almost a decade after their discovery, the function of reggies/flotillins is still enigmatic. In this review we summarize the present state of knowledge on reggie/flotillin structure, localization and function, and discuss the role of the proteins in development and disease. Based on insights into reggie/flotillin function and by comparison with related proteins of the so-called SPFH (Stomatin/Prohibitin/Flotillin/HflK/C) protein family, including stomatin, podocin and prohibitin, we propose the existence of specific types of protein-defined microdomains which are sculpt by the clustering of individual SPFH proteins. As "specialized rafts" similar to caveolae, these membrane domains provide platforms for the recruitment of multiprotein complexes. Since, under certain circumstances, reggie-2/flotillin-1 translocates to the nucleus, reggie/flotillin microdomains are not only stable scaffolds but also dynamic units with their own regulatory functions.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Lipid raft microdomains, signaling scaffolds, actin cytoskeleton, SPFH domain, stomatin, podocin, prohibitin, caveolae

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690LANGHORST, Matthias F., Alexander REUTER, Claudia STÜRMER, 2005. Scaffolding microdomains and beyond : the function of reggie/flotillin proteins. In: Cellular and Molecular Life Science. 2005, 62(19-20), pp. 2228-2240. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-005-5166-4
BibTex
@article{Langhorst2005Scaff-8256,
  year={2005},
  doi={10.1007/s00018-005-5166-4},
  title={Scaffolding microdomains and beyond : the function of reggie/flotillin proteins},
  number={19-20},
  volume={62},
  issn={1420-682X},
  journal={Cellular and Molecular Life Science},
  pages={2228--2240},
  author={Langhorst, Matthias F. and Reuter, Alexander and Stürmer, Claudia}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/8256">
    <dcterms:title>Scaffolding microdomains and beyond : the function of reggie/flotillin proteins</dcterms:title>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Reuter, Alexander</dc:creator>
    <dc:contributor>Langhorst, Matthias F.</dc:contributor>
    <dc:contributor>Reuter, Alexander</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8256/1/115_Scaffolding_microdomains_and_beyond.pdf"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:11Z</dcterms:available>
    <dc:contributor>Stürmer, Claudia</dc:contributor>
    <dc:creator>Langhorst, Matthias F.</dc:creator>
    <dc:creator>Stürmer, Claudia</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dcterms:issued>2005</dcterms:issued>
    <dcterms:bibliographicCitation>First publ. in: Cellular and Molecular Life Science 62 (2005), pp. 2228-2240</dcterms:bibliographicCitation>
    <dc:language>eng</dc:language>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8256"/>
    <dcterms:abstract xml:lang="eng">Reggie/flotillin proteins are considered to be components of lipid rafts and are commonly used as marker proteins for lipid microdomains. Yet almost a decade after their discovery, the function of reggies/flotillins is still enigmatic. In this review we summarize the present state of knowledge on reggie/flotillin structure, localization and function, and discuss the role of the proteins in development and disease. Based on insights into reggie/flotillin function and by comparison with related proteins of the so-called SPFH (Stomatin/Prohibitin/Flotillin/HflK/C) protein family, including stomatin, podocin and prohibitin, we propose the existence of specific types of protein-defined microdomains which are sculpt by the clustering of individual SPFH proteins. As "specialized rafts" similar to caveolae, these membrane domains provide platforms for the recruitment of multiprotein complexes. Since, under certain circumstances, reggie-2/flotillin-1 translocates to the nucleus, reggie/flotillin microdomains are not only stable scaffolds but also dynamic units with their own regulatory functions.</dcterms:abstract>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:42:11Z</dc:date>
    <dc:format>application/pdf</dc:format>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8256/1/115_Scaffolding_microdomains_and_beyond.pdf"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen