Publikation: Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish
Lade...
Dateien
Datum
1996
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Toxicology. 1996, 106(1-3), pp. 123-130. ISSN 0300-483X. Available under: doi: 10.1016/0300-483X(95)03173-D
Zusammenfassung
Previous reports demonstrated that microcystin and related cyanobacteria polypeptides are rapidly cleared from plasma and accumulate in liver tissue. In the present study, we have used their ability to inhibit protein phosphatases to show that these cyanobacteria hepatotoxins are excreted into the bile of experimentally poisoned rainbow trout. At various times after oral administration of hepatotoxic Microcystis aeruginosa, bile samples were analysed for microcystin content by methanol extraction and protein phosphatase assays. An inhibitory principle that specifically suppressed protein phosphatase activity was detected in all bile samples removed between 1 and 72 h after oral exposure to toxic algae. These results indicate that biochemically active microcystin molecules are excreted into the biliary tract of poisoned fish.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Microcystin, Hepatotoxicity, Phosphatase, Organic ion transporter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
SAHIN, Ali, Francesca G. TENCALLA, Daniel R. DIETRICH, Hanspeter NAEGELI, 1996. Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish. In: Toxicology. 1996, 106(1-3), pp. 123-130. ISSN 0300-483X. Available under: doi: 10.1016/0300-483X(95)03173-DBibTex
@article{Sahin1996Bilia-7736,
year={1996},
doi={10.1016/0300-483X(95)03173-D},
title={Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish},
number={1-3},
volume={106},
issn={0300-483X},
journal={Toxicology},
pages={123--130},
author={Sahin, Ali and Tencalla, Francesca G. and Dietrich, Daniel R. and Naegeli, Hanspeter}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7736">
<dc:contributor>Naegeli, Hanspeter</dc:contributor>
<dc:creator>Naegeli, Hanspeter</dc:creator>
<dcterms:title>Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish</dcterms:title>
<dc:format>application/pdf</dc:format>
<dc:contributor>Tencalla, Francesca G.</dc:contributor>
<dcterms:abstract xml:lang="eng">Previous reports demonstrated that microcystin and related cyanobacteria polypeptides are rapidly cleared from plasma and accumulate in liver tissue. In the present study, we have used their ability to inhibit protein phosphatases to show that these cyanobacteria hepatotoxins are excreted into the bile of experimentally poisoned rainbow trout. At various times after oral administration of hepatotoxic Microcystis aeruginosa, bile samples were analysed for microcystin content by methanol extraction and protein phosphatase assays. An inhibitory principle that specifically suppressed protein phosphatase activity was detected in all bile samples removed between 1 and 72 h after oral exposure to toxic algae. These results indicate that biochemically active microcystin molecules are excreted into the biliary tract of poisoned fish.</dcterms:abstract>
<dc:creator>Tencalla, Francesca G.</dc:creator>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7736/1/Biliary_excretion_of_biochemically_active_cyanobacteria.pdf"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:08Z</dc:date>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:language>eng</dc:language>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7736/1/Biliary_excretion_of_biochemically_active_cyanobacteria.pdf"/>
<dc:creator>Sahin, Ali</dc:creator>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:08Z</dcterms:available>
<dc:contributor>Sahin, Ali</dc:contributor>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7736"/>
<dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
<dc:creator>Dietrich, Daniel R.</dc:creator>
<dcterms:issued>1996</dcterms:issued>
<dcterms:bibliographicCitation>First publ. in: Toxicology 106 (1996), 1-3, pp. 123-130</dcterms:bibliographicCitation>
<dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:contributor>Dietrich, Daniel R.</dc:contributor>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
