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Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology

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Kinnersley_2-fr038sak7soi3.pdf
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Datum

2024

Autor:innen

Kinnersley, Ben
Sud, Amit
Everall, Andrew
Cornish, Alex J.
Chubb, Daniel
Culliford, Richard
Lärkeryd, Adrian
Mitsopoulos, Costas
Houlston, Richard
et al.

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Nature Genetics. Springer. 2024, 56(9), S. 1868-1877. ISSN 1061-4036. eISSN 1546-1718. Verfügbar unter: doi: 10.1038/s41588-024-01785-9

Zusammenfassung

Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of patients with cancer. To explore the value of whole-genome sequencing (WGS) in broadening the scope of cancers potentially amenable to a precision therapy, we analysed whole-genome sequencing data on 10,478 patients spanning 35 cancer types recruited to the UK 100,000 Genomes Project. We identified 330 candidate driver genes, including 74 that are new to any cancer. We estimate that approximately 55% of patients studied harbor at least one clinically relevant mutation, predicting either sensitivity or resistance to certain treatments or clinical trial eligibility. By performing computational chemogenomic analysis of cancer mutations we identify additional targets for compounds that represent attractive candidates for future clinical trials. This study represents one of the most comprehensive efforts thus far to identify cancer driver genes in the real world setting and assess their impact on informing precision oncology.

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570 Biowissenschaften, Biologie

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ISO 690KINNERSLEY, Ben, Amit SUD, Andrew EVERALL, Alex J. CORNISH, Daniel CHUBB, Richard CULLIFORD, Andreas J. GRUBER, Adrian LÄRKERYD, Costas MITSOPOULOS, Richard HOULSTON, 2024. Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology. In: Nature Genetics. Springer. 2024, 56(9), S. 1868-1877. ISSN 1061-4036. eISSN 1546-1718. Verfügbar unter: doi: 10.1038/s41588-024-01785-9
BibTex
@article{Kinnersley2024-09Analy-70433,
  year={2024},
  doi={10.1038/s41588-024-01785-9},
  title={Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology},
  number={9},
  volume={56},
  issn={1061-4036},
  journal={Nature Genetics},
  pages={1868--1877},
  author={Kinnersley, Ben and Sud, Amit and Everall, Andrew and Cornish, Alex J. and Chubb, Daniel and Culliford, Richard and Gruber, Andreas J. and Lärkeryd, Adrian and Mitsopoulos, Costas and Houlston, Richard}
}
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