Publikation:

Modulation of epigenetic regulators and cell fate decisions by miRNAs

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Gruber_2-fj0xs8f55p6p3.pdf
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Datum

2013

Autor:innen

Zavolan, Mihaela

Herausgeber:innen

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-fj0xs8f55p6p3
DOI (zitierfähiger Link)
https://doi.org/10.2217/epi.13.65
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Open Access-Veröffentlichung
Open Access Hybrid

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Biologie: Publikationen
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Published

Erschienen in

Epigenomics. Future Medicine. 2013, 5(6), pp. 671-683. ISSN 1750-1911. eISSN 1750-192X. Available under: doi: 10.2217/epi.13.65

Zusammenfassung

Mammalian gene expression is controlled at multiple levels by a variety of regulators, including chromatin modifiers, transcription factors and miRNAs. The latter are small, ncRNAs that inhibit the expression of target mRNAs by reducing both their stability and translation rate. In this review, we summarize the recent work towards characterizing miRNA targets that are themselves involved in the regulation of gene expression at the epigenetic level. Epigenetic regulators are strongly enriched among the predicted targets of miRNAs, which may contribute to the documented importance of miRNAs for pluripotency, organism development and somatic cell reprogramming.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

BAF, epigenetic regulator, epigenetics, iPSC, miR-290–295, miRNA, pluripotent stem cell, reprogramming, transcription factor

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ISO 690GRUBER, Andreas J., Mihaela ZAVOLAN, 2013. Modulation of epigenetic regulators and cell fate decisions by miRNAs. In: Epigenomics. Future Medicine. 2013, 5(6), pp. 671-683. ISSN 1750-1911. eISSN 1750-192X. Available under: doi: 10.2217/epi.13.65
BibTex
@article{Gruber2013-12Modul-50927,
  year={2013},
  doi={10.2217/epi.13.65},
  title={Modulation of epigenetic regulators and cell fate decisions by miRNAs},
  number={6},
  volume={5},
  issn={1750-1911},
  journal={Epigenomics},
  pages={671--683},
  author={Gruber, Andreas J. and Zavolan, Mihaela}
}
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Interner Vermerk

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