Understanding p53 tumour suppressor network

Panatta, Emanuele; Zampieri, Carlotta; Melino, Gerry; Amelio, Ivano

Understanding p53 tumour suppressor network

Dateien

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Datum

2021

Autor:innen

Panatta, Emanuele

Zampieri, Carlotta

Melino, Gerry

Amelio, Ivano

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Biology Direct. BioMed Central. 2021, 16, 14. eISSN 1745-6150. Available under: doi: 10.1186/s13062-021-00298-3

Zusammenfassung

The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic stress. In the recent years additional p53-mediated tumour suppression mechanisms have been described, questioning the contribution of its canonical pathway for tumour suppression. These include regulation of alternative cell death modalities (i.e. ferroptosis), cell metabolism and the emerging role in RNA stability. Here we briefly summarize our knowledge on p53 "canonical DNA damage response" and discuss the most relevant recent findings describing potential mechanistic explanation of p53-mediated tumour suppression.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Tumour suppression, DNA damage, Stress response, Cell death

Zitieren

ISO 690

PANATTA, Emanuele, Carlotta ZAMPIERI, Gerry MELINO, Ivano AMELIO, 2021. Understanding p53 tumour suppressor network. In: Biology Direct. BioMed Central. 2021, 16, 14. eISSN 1745-6150. Available under: doi: 10.1186/s13062-021-00298-3

BibTex

@article{Panatta2021Under-56466,
  year={2021},
  doi={10.1186/s13062-021-00298-3},
  title={Understanding p53 tumour suppressor network},
  volume={16},
  journal={Biology Direct},
  author={Panatta, Emanuele and Zampieri, Carlotta and Melino, Gerry and Amelio, Ivano},
  note={Article Number: 14}
}

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Universitätsbibliographie

Nein

Begutachtet

Ja