Understanding p53 tumour suppressor network

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2021
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Panatta, Emanuele
Zampieri, Carlotta
Melino, Gerry
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Published
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Biology Direct. BioMed Central. 2021, 16, 14. eISSN 1745-6150. Available under: doi: 10.1186/s13062-021-00298-3
Zusammenfassung

The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic stress. In the recent years additional p53-mediated tumour suppression mechanisms have been described, questioning the contribution of its canonical pathway for tumour suppression. These include regulation of alternative cell death modalities (i.e. ferroptosis), cell metabolism and the emerging role in RNA stability. Here we briefly summarize our knowledge on p53 "canonical DNA damage response" and discuss the most relevant recent findings describing potential mechanistic explanation of p53-mediated tumour suppression.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Tumour suppression, DNA damage, Stress response, Cell death
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Zitieren
ISO 690PANATTA, Emanuele, Carlotta ZAMPIERI, Gerry MELINO, Ivano AMELIO, 2021. Understanding p53 tumour suppressor network. In: Biology Direct. BioMed Central. 2021, 16, 14. eISSN 1745-6150. Available under: doi: 10.1186/s13062-021-00298-3
BibTex
@article{Panatta2021Under-56466,
  year={2021},
  doi={10.1186/s13062-021-00298-3},
  title={Understanding p53 tumour suppressor network},
  volume={16},
  journal={Biology Direct},
  author={Panatta, Emanuele and Zampieri, Carlotta and Melino, Gerry and Amelio, Ivano},
  note={Article Number: 14}
}
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