Publikation: Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa
Lade...
Dateien
Datum
2018
Autor:innen
Zhu, Yan
Czauderna, Tobias
Zhao, Jinxin
Klapperstueck, Matthias
Maifiah, Mohd Hafidz Mahamad
Han, Mei-Ling
Lu, Jing
Li, Jian
et al.
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
GigaScience. 2018, 7(4), giy018. eISSN 2047-217X. Available under: doi: 10.1093/gigascience/giy021
Zusammenfassung
Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients, and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics, it is necessary to systematically understand how P. aeruginosa alters its metabolism in response to polymyxin treatment, thereby facilitating the development of effective therapies. To this end, a genome-scale metabolic model (GSMM) was used to analyze bacterial metabolic changes at the systems level.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
004 Informatik
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
ZHU, Yan, Tobias CZAUDERNA, Jinxin ZHAO, Matthias KLAPPERSTUECK, Mohd Hafidz Mahamad MAIFIAH, Mei-Ling HAN, Jing LU, Björn SOMMER, Falk SCHREIBER, Jian LI, 2018. Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa. In: GigaScience. 2018, 7(4), giy018. eISSN 2047-217X. Available under: doi: 10.1093/gigascience/giy021BibTex
@article{Zhu2018Genom-42970,
year={2018},
doi={10.1093/gigascience/giy021},
title={Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa},
number={4},
volume={7},
journal={GigaScience},
author={Zhu, Yan and Czauderna, Tobias and Zhao, Jinxin and Klapperstueck, Matthias and Maifiah, Mohd Hafidz Mahamad and Han, Mei-Ling and Lu, Jing and Sommer, Björn and Schreiber, Falk and Li, Jian},
note={Article Number: giy018}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/42970">
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
<dc:contributor>Maifiah, Mohd Hafidz Mahamad</dc:contributor>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42970/3/Zhu_2-esm0xmgvxmn56.pdf"/>
<dc:contributor>Klapperstueck, Matthias</dc:contributor>
<dc:language>eng</dc:language>
<dc:creator>Zhu, Yan</dc:creator>
<dc:contributor>Zhao, Jinxin</dc:contributor>
<dcterms:title>Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa</dcterms:title>
<dcterms:abstract xml:lang="eng">Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients, and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics, it is necessary to systematically understand how P. aeruginosa alters its metabolism in response to polymyxin treatment, thereby facilitating the development of effective therapies. To this end, a genome-scale metabolic model (GSMM) was used to analyze bacterial metabolic changes at the systems level.</dcterms:abstract>
<dc:contributor>Han, Mei-Ling</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dcterms:issued>2018</dcterms:issued>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-08-06T10:42:16Z</dcterms:available>
<dc:contributor>Zhu, Yan</dc:contributor>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-08-06T10:42:16Z</dc:date>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42970/3/Zhu_2-esm0xmgvxmn56.pdf"/>
<dc:creator>Klapperstueck, Matthias</dc:creator>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
<dc:creator>Zhao, Jinxin</dc:creator>
<dc:creator>Maifiah, Mohd Hafidz Mahamad</dc:creator>
<dc:rights>Attribution 4.0 International</dc:rights>
<dc:contributor>Schreiber, Falk</dc:contributor>
<dc:creator>Li, Jian</dc:creator>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42970"/>
<dc:contributor>Li, Jian</dc:contributor>
<dc:creator>Sommer, Björn</dc:creator>
<dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
<dc:creator>Han, Mei-Ling</dc:creator>
<dc:creator>Czauderna, Tobias</dc:creator>
<dc:creator>Lu, Jing</dc:creator>
<dc:contributor>Lu, Jing</dc:contributor>
<dc:creator>Schreiber, Falk</dc:creator>
<dc:contributor>Czauderna, Tobias</dc:contributor>
<dc:contributor>Sommer, Björn</dc:contributor>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Unbekannt
