Publikation: The Deubiquitinating Enzyme AMSH3 Is Required for Intracellular Trafficking and Vacuole Biogenesis in Arabidopsis thaliana
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Datum
2010
Autor:innen
Katsiarimpa, Anthi
Müller, Isabel Karin
Anzenberger, Franziska
Stierhof, York-Dieter
Geldner, Niko
Chory, Joanne
Schwechheimer, Claus
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The Plant Cell. 2010, 22(6), pp. 1826-1837. ISSN 1040-4651. eISSN 1532-298X. Available under: doi: 10.1105/tpc.110.075952
Zusammenfassung
Ubiquitination, deubiquitination, and the formation of specific ubiquitin chain topologies have been implicated in various cellular processes. Little is known, however, about the role of ubiquitin in the development of cellular organelles. Here, we identify and characterize the deubiquitinating enzyme AMSH3 from Arabidopsis thaliana. AMSH3 hydrolyzes K48- and K63-linked ubiquitin chains in vitro and accumulates both ubiquitin chain types in vivo. amsh3 mutants fail to form a central lytic vacuole, accumulate autophagosomes, and mis-sort vacuolar protein cargo to the intercellular space. Furthermore, AMSH3 is required for efficient endocytosis of the styryl dye FM4-64 and the auxin efflux facilitator PIN2. We thus present evidence for a role of deubiquitination in intracellular trafficking and vacuole biogenesis.
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570 Biowissenschaften, Biologie
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ISONO, Erika, Anthi KATSIARIMPA, Isabel Karin MÜLLER, Franziska ANZENBERGER, York-Dieter STIERHOF, Niko GELDNER, Joanne CHORY, Claus SCHWECHHEIMER, 2010. The Deubiquitinating Enzyme AMSH3 Is Required for Intracellular Trafficking and Vacuole Biogenesis in Arabidopsis thaliana. In: The Plant Cell. 2010, 22(6), pp. 1826-1837. ISSN 1040-4651. eISSN 1532-298X. Available under: doi: 10.1105/tpc.110.075952BibTex
@article{Isono2010-06Deubi-42124,
year={2010},
doi={10.1105/tpc.110.075952},
title={The Deubiquitinating Enzyme AMSH3 Is Required for Intracellular Trafficking and Vacuole Biogenesis in Arabidopsis thaliana},
number={6},
volume={22},
issn={1040-4651},
journal={The Plant Cell},
pages={1826--1837},
author={Isono, Erika and Katsiarimpa, Anthi and Müller, Isabel Karin and Anzenberger, Franziska and Stierhof, York-Dieter and Geldner, Niko and Chory, Joanne and Schwechheimer, Claus}
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<dcterms:abstract xml:lang="eng">Ubiquitination, deubiquitination, and the formation of specific ubiquitin chain topologies have been implicated in various cellular processes. Little is known, however, about the role of ubiquitin in the development of cellular organelles. Here, we identify and characterize the deubiquitinating enzyme AMSH3 from Arabidopsis thaliana. AMSH3 hydrolyzes K48- and K63-linked ubiquitin chains in vitro and accumulates both ubiquitin chain types in vivo. amsh3 mutants fail to form a central lytic vacuole, accumulate autophagosomes, and mis-sort vacuolar protein cargo to the intercellular space. Furthermore, AMSH3 is required for efficient endocytosis of the styryl dye FM4-64 and the auxin efflux facilitator PIN2. We thus present evidence for a role of deubiquitination in intracellular trafficking and vacuole biogenesis.</dcterms:abstract>
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