RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors

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1993
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Bischoff, Stephan C.
Krieger, Martin
Rot, Antal
Tscharner, Vincenz von
Baggiolini, Marco
Dahinden, Clemens A.
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European Journal of Immunology ; 23 (1993), 3. - pp. 761-767. - ISSN 0014-2980
Abstract
Chemotactic cytokines related to interleukin-8 (IL-8; CXC-chemokines) or monocyte chemotactic protein-1 (MCP-1; CC-chemokines) have been shown to stimulate human basophils, and are considered important tissue-derived mediators of inflammation. We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-lα (MlP-lα) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. MCP-1 was the most potent stimulus of release, and the only chemokine that induced marked exocytosis in basophils without pretreatment with interleukin-3. RANTES was the strongest stimulus of chemotaxis, but only a moderate stimulus of release. MIP-lα elicited relatively weak chemotaxis and release responses, but was effective at considerably lower concentrations than MCP-1 and RANTES. MIP-1β, by contrast, despite its high homology to MlP-lα, was totally inactive. Normodense human eosinophils, tested for comparison, responded in a similar fashion to RANTES and MIP-lα, but were unresponsive to MCP-1 and MIP-lβ. All CC-chemokines except MIP-lβ induced a similar rapid and transient rise of [Ca2+]| that was sensitive to pertussis toxin, indicating that they activate basophils via G-protein-coupled receptors. Cross-desensensitization experiments indicate that basophils bear different CC-chemokine receptors. Some interact selectively with MCP-1 or RANTES, while others are shared by RANTES and MlP-lα.
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570 Biosciences, Biology
Keywords
Chemokines,RANTES,Basophils,Chemotaxis,Leukotrienes
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ISO 690BISCHOFF, Stephan C., Martin KRIEGER, Thomas BRUNNER, Antal ROT, Vincenz von TSCHARNER, Marco BAGGIOLINI, Clemens A. DAHINDEN, 1993. RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. In: European Journal of Immunology. 23(3), pp. 761-767. ISSN 0014-2980. Available under: doi: 10.1002/eji.1830230329
BibTex
@article{Bischoff1993-03RANTE-14339,
  year={1993},
  doi={10.1002/eji.1830230329},
  title={RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors},
  number={3},
  volume={23},
  issn={0014-2980},
  journal={European Journal of Immunology},
  pages={761--767},
  author={Bischoff, Stephan C. and Krieger, Martin and Brunner, Thomas and Rot, Antal and Tscharner, Vincenz von and Baggiolini, Marco and Dahinden, Clemens A.}
}
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