Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

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ExpGerontology_2007_Kunzmann_et_al.pdf
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2007
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Kunzmann, Andrea
Dedoussis, George
Jajte, Jolanta
Malavolta, Marco
Mocchegiani, Eugenio
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Experimental Gerontology. 2007, 43(5), pp. 409-414. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2007.10.003
Zusammenfassung

Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.

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570 Biowissenschaften, Biologie
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PARP-1, Poly(ADP-ribosyl)ation capacity, Zinc supplementation, Aging
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ISO 690KUNZMANN, Andrea, George DEDOUSSIS, Jolanta JAJTE, Marco MALAVOLTA, Eugenio MOCCHEGIANI, Alexander BÜRKLE, 2007. Effect of zinc on cellular poly(ADP-ribosyl)ation capacity. In: Experimental Gerontology. 2007, 43(5), pp. 409-414. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2007.10.003
BibTex
@article{Kunzmann2007Effec-8768,
  year={2007},
  doi={10.1016/j.exger.2007.10.003},
  title={Effect of zinc on cellular poly(ADP-ribosyl)ation capacity},
  number={5},
  volume={43},
  issn={0531-5565},
  journal={Experimental Gerontology},
  pages={409--414},
  author={Kunzmann, Andrea and Dedoussis, George and Jajte, Jolanta and Malavolta, Marco and Mocchegiani, Eugenio and Bürkle, Alexander}
}
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