Publikation:

Effect of zinc on cellular poly(ADP-ribosyl)ation capacity

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ExpGerontology_2007_Kunzmann_et_al.pdf
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2007

Autor:innen

Kunzmann, Andrea
Dedoussis, George
Jajte, Jolanta
Malavolta, Marco
Mocchegiani, Eugenio

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-77519
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.exger.2007.10.003
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Open Access-Veröffentlichung
Open Access Green

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Biologie: Publikationen
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Published

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Experimental Gerontology. 2007, 43(5), pp. 409-414. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2007.10.003

Zusammenfassung

Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p < 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

PARP-1, Poly(ADP-ribosyl)ation capacity, Zinc supplementation, Aging

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ISO 690KUNZMANN, Andrea, George DEDOUSSIS, Jolanta JAJTE, Marco MALAVOLTA, Eugenio MOCCHEGIANI, Alexander BÜRKLE, 2007. Effect of zinc on cellular poly(ADP-ribosyl)ation capacity. In: Experimental Gerontology. 2007, 43(5), pp. 409-414. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2007.10.003
BibTex
@article{Kunzmann2007Effec-8768,
  year={2007},
  doi={10.1016/j.exger.2007.10.003},
  title={Effect of zinc on cellular poly(ADP-ribosyl)ation capacity},
  number={5},
  volume={43},
  issn={0531-5565},
  journal={Experimental Gerontology},
  pages={409--414},
  author={Kunzmann, Andrea and Dedoussis, George and Jajte, Jolanta and Malavolta, Marco and Mocchegiani, Eugenio and Bürkle, Alexander}
}
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    <dcterms:abstract xml:lang="eng">Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p &lt; 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.</dcterms:abstract>
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