@article{Schindler2018Kinky-45161,
  year={2018},
  doi={10.1103/PhysRevE.98.042417},
  title={Kinky DNA in solution : Small-angle-scattering study of a nucleosome positioning sequence},
  number={4},
  volume={98},
  issn={2470-0045},
  journal={Physical Review E},
  author={Schindler, Torben and González, Adrián and Boopathi, Ramachandran and Roda, Marta Marty and Romero-Santacreu, Lorena and Wildes, Andrew and Porcar, Lionel and Martel, Anne and Theodorakopoulos, Nikos and Peyrard, Michel},
  note={Article Number: 042417}
}

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    <dc:contributor>Porcar, Lionel</dc:contributor>
    <dc:creator>Peyrard, Michel</dc:creator>
    <dc:contributor>Theodorakopoulos, Nikos</dc:contributor>
    <dc:contributor>Peyrard, Michel</dc:contributor>
    <dc:contributor>Roda, Marta Marty</dc:contributor>
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    <dc:creator>Wildes, Andrew</dc:creator>
    <dc:creator>Romero-Santacreu, Lorena</dc:creator>
    <dc:creator>González, Adrián</dc:creator>
    <dc:contributor>Romero-Santacreu, Lorena</dc:contributor>
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    <dc:contributor>González, Adrián</dc:contributor>
    <dcterms:issued>2018</dcterms:issued>
    <dc:contributor>Martel, Anne</dc:contributor>
    <dc:creator>Roda, Marta Marty</dc:creator>
    <dc:creator>Boopathi, Ramachandran</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Wildes, Andrew</dc:contributor>
    <dc:contributor>Boopathi, Ramachandran</dc:contributor>
    <dcterms:abstract xml:lang="eng">DNA is a flexible molecule, but the degree of its flexibility is subject to debate. The commonly-accepted persistence length of l&lt;sub&gt;p&lt;/sub&gt;≈500Å is inconsistent with recent studies on short-chain DNA that show much greater flexibility but do not probe its origin. We have performed x-ray and neutron small-angle scattering on a short DNA sequence containing a strong nucleosome positioning element and analyzed the results using a modified Kratky-Porod model to determine possible conformations. Our results support a hypothesis from Crick and Klug in 1975 that some DNA sequences in solution can have sharp kinks, potentially resolving the discrepancy. Our conclusions are supported by measurements on a radiation-damaged sample, where single-strand breaks lead to increased flexibility and by an analysis of data from another sequence, which does not have kinks, but where our method can detect a locally enhanced flexibility due to an AT domain.</dcterms:abstract>
    <dc:creator>Schindler, Torben</dc:creator>
    <dcterms:title>Kinky DNA in solution : Small-angle-scattering study of a nucleosome positioning sequence</dcterms:title>
    <dc:contributor>Schindler, Torben</dc:contributor>
    <dc:creator>Martel, Anne</dc:creator>
    <dc:creator>Theodorakopoulos, Nikos</dc:creator>
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