Cigarette smoking, blood lipids, and baroreceptor-modulated nociception

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1993
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Rau, Harald
Schweizer, Renate
Zhuang, Ping
Pauli, Paul
Brody, Stuart
Larbig, Wolfgang
Heinle, Helmut
Müller, Matthias
Dworkin, Barry R.
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Psychopharmacology. 1993, 110(3), pp. 337-341. Available under: doi: 10.1007/BF02251290
Zusammenfassung

Activation of arterial blood pressure has been shown to influence higher central nervous activity. In animals, induction of sleep-like states and increases of seizure and pain thresholds in response to baroreceptor stimulation have been reported. In certain human groups, mechanical stimulation of the carotid baroreceptors also increases pain thresholds. The present paper examines the hypothesis that smokers show baroreceptor dependent antinociception as compared to non-smokers. It is speculated that one effect which rewards smoking is the nicotine induced phasic blood pressure increase which leads to baroreceptor stimulation and dampens pain perception. One hundred and twenty subjects were investigated using a recently developed mechanical baroreceptor stimulation technique and an electrical pain stimulus. The group of heavy smokers showed the predicted effect: their pain thresholds were enhanced during conditions of increased baroreceptor activity as compared to the control condition. The group of medium, light and non-smokers, however, did not show this effect. Neither blood lipid levels nor diastolic or systolic blood pressure paralleled the group differences on baroreceptor dependent antinociception. In heavy smokers, the nicotine induced phasic blood pressure increases might have baroreceptor dependent pain dampening effects, which might be among the reinforcing qualities of smoking.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Pain, Baroreceptor stimulation, PRES, Smoking, Nicotine, Blood lipid levels, Cholesterol
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ISO 690RAU, Harald, Renate SCHWEIZER, Ping ZHUANG, Paul PAULI, Stuart BRODY, Wolfgang LARBIG, Helmut HEINLE, Matthias MÜLLER, Thomas ELBERT, Barry R. DWORKIN, Niels BIRBAUMER, 1993. Cigarette smoking, blood lipids, and baroreceptor-modulated nociception. In: Psychopharmacology. 1993, 110(3), pp. 337-341. Available under: doi: 10.1007/BF02251290
BibTex
@article{Rau1993Cigar-10809,
  year={1993},
  doi={10.1007/BF02251290},
  title={Cigarette smoking, blood lipids, and baroreceptor-modulated nociception},
  number={3},
  volume={110},
  journal={Psychopharmacology},
  pages={337--341},
  author={Rau, Harald and Schweizer, Renate and Zhuang, Ping and Pauli, Paul and Brody, Stuart and Larbig, Wolfgang and Heinle, Helmut and Müller, Matthias and Elbert, Thomas and Dworkin, Barry R. and Birbaumer, Niels}
}
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