CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth

Lang, Dirk M.; Rubin, Beatrix P.; Schwab, Martin E.; Stürmer, Claudia

CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth

Dateien

CNS_Myelin_1995.pdfGröße: 2.36 MBDownloads: 710

Datum

1995

Autor:innen

Lang, Dirk M.

Rubin, Beatrix P.

Schwab, Martin E.

Stürmer, Claudia

Publikationstyp

Zeitschriftenartikel

unikn.publication.listelement.citation.prefix.version.undefined

The Journal of Neuroscience. 1995, 15(1), pp. 99-109

Zusammenfassung

In vitro assays reveal that myelin and oligodendrocytes of the Xenopus spinal cord (SC) are - unlike corresponding components of the optic nerve/tectum (OT) - nonpermissive substrates for regenerating retinal axons. The number of growth cones that crossed SC oligodendrocytes is low but increases significantly (four- to fivefold) in the presence of the antibody IN-l, in which case their numbers are similar to the number of growth cones (-60%) that cross OT oligodendrocytes with or without IN-l. IN-1 neutralizes neurite growth inhibitors (NI) of rat CNS myelin, indicating that mammalian-like NI are associated with Xenopus SC myelin and oligodendrocytes but not with the OT. IN-1 immunocytochemistry on sections supports this view: SC myelin was stained with IN-l, whereas OT myelin and PNS myelin were not.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

CNS myelin/oligodendrocytes, Xenopus, differences in substrate properties, neurite growth inhibitors, in vitro assays

Zitieren

ISO 690

LANG, Dirk M., Beatrix P. RUBIN, Martin E. SCHWAB, Claudia STÜRMER, 1995. CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth. In: The Journal of Neuroscience. 1995, 15(1), pp. 99-109

BibTex

@article{Lang1995myeli-7157,
  year={1995},
  title={CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth},
  number={1},
  volume={15},
  journal={The Journal of Neuroscience},
  pages={99--109},
  author={Lang, Dirk M. and Rubin, Beatrix P. and Schwab, Martin E. and Stürmer, Claudia}
}

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