CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth

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CNS_Myelin_1995.pdf
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1995
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Lang, Dirk M.
Rubin, Beatrix P.
Schwab, Martin E.
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Zusammenfassung

In vitro assays reveal that myelin and oligodendrocytes of the Xenopus spinal cord (SC) are - unlike corresponding components of the optic nerve/tectum (OT) - nonpermissive substrates for regenerating retinal axons. The number of growth cones that crossed SC oligodendrocytes is low but increases significantly (four- to fivefold) in the presence of the antibody IN-l, in which case their numbers are similar to the number of growth cones (-60%) that cross OT oligodendrocytes with or without IN-l. IN-1 neutralizes neurite growth inhibitors (NI) of rat CNS myelin, indicating that mammalian-like NI are associated with Xenopus SC myelin and oligodendrocytes but not with the OT. IN-1 immunocytochemistry on sections supports this view: SC myelin was stained with IN-l, whereas OT myelin and PNS myelin were not.

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570 Biowissenschaften, Biologie
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CNS myelin/oligodendrocytes, Xenopus, differences in substrate properties, neurite growth inhibitors, in vitro assays
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ISO 690LANG, Dirk M., Beatrix P. RUBIN, Martin E. SCHWAB, Claudia STÜRMER, 1995. CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth. In: The Journal of Neuroscience. 1995, 15(1), pp. 99-109
BibTex
@article{Lang1995myeli-7157,
  year={1995},
  title={CNS myelin and oligodendrocytes of the Xenopus spinal cord - but not optic nerve - are nonpermissive for axon growth},
  number={1},
  volume={15},
  journal={The Journal of Neuroscience},
  pages={99--109},
  author={Lang, Dirk M. and Rubin, Beatrix P. and Schwab, Martin E. and Stürmer, Claudia}
}
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