Reporter ribozymes for domain-specific-real-time analysis of biomolecular interactions : HIV-1-reverse transcriptase and the primer-template complex

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2002
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Famulok, Michael
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Zusammenfassung

By fusing an aptamer to a ribozyme, an aptazyme was constructed (see picture) which sensitively and specifically detects the presence of HIV-1 reverse transcriptase (RT). The fusion construct not only serves as a biosensor, but is also well suited for screening lead structures binding to the primer/template binding site of HIV-1 RT.

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540 Chemie
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hammerhead ribozyme, proteins, reverse transcriptase, ribozymes, RNA, RNA–protein interactions
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ISO 690HARTIG, Jörg S., Michael FAMULOK, 2002. Reporter ribozymes for domain-specific-real-time analysis of biomolecular interactions : HIV-1-reverse transcriptase and the primer-template complex. In: Angewandte Chemie International Edition. 2002, 41(22), pp. 4263-4266. ISSN 1433-7851. Available under: doi: 10.1002/1521-3773(20021115)41:22<4263::AID-ANIE4263>3.0.CO;2-7
BibTex
@article{Hartig2002Repor-15660,
  year={2002},
  doi={10.1002/1521-3773(20021115)41:22<4263::AID-ANIE4263>3.0.CO;2-7},
  title={Reporter ribozymes for domain-specific-real-time analysis of biomolecular interactions : HIV-1-reverse transcriptase and the primer-template complex},
  number={22},
  volume={41},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={4263--4266},
  author={Hartig, Jörg S. and Famulok, Michael}
}
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