n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings

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2015
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Israel, Mimi
Klein, Michael
Thaler, Lea
Spilka, Michael
Efanov, Simona
Ouellette, Anne-Sophie
Berlim, Marcelo
Ali, Nida
Steiger, Howard
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Eating disorder (ED) variants characterized by "binge-eating/purging" symptoms differ from "restricting-only" variants along diverse clinical dimensions, but few studies have compared people with these different eating-disorder phenotypes on measures of neurocognitive function and brain activation. We tested the performances of 19 women with "restricting-only" eating syndromes and 27 with "binge-eating/purging" variants on a modified n-back task, and used functional magnetic resonance imaging (fMRI) to examine task-induced brain activations in frontal regions of interest. When compared with "binge-eating/purging" participants, "restricting-only" participants showed superior performance. Furthermore, in an intermediate-demand condition, "binge-eating/purging" participants showed significantly less event-related activation than did "restricting-only" participants in a right posterior prefrontal region spanning Brodmann areas 6-8-a region that has been linked to planning of motor responses, working memory for sequential information, and management of uncertainty. Our findings suggest that working memory is poorer in eating-disordered individuals with binge-eating/purging behaviors than in those who solely restrict food intake, and that observed performance differences coincide with interpretable group-based activation differences in a frontal region thought to subserve planning and decision making.

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Fachgebiet (DDC)
150 Psychologie
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Eating disorders; Functional neuroimaging; Executive function; Anorexia; Bulimia; Binge eating
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ISO 690ISRAEL, Mimi, Michael KLEIN, Jens C. PRUESSNER, Lea THALER, Michael SPILKA, Simona EFANOV, Anne-Sophie OUELLETTE, Marcelo BERLIM, Nida ALI, Howard STEIGER, 2015. n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings. In: Psychiatry Research : Neuroimaging. 2015, 232(1), pp. 84-91. ISSN 0925-4927. eISSN 1872-7123. Available under: doi: 10.1016/j.pscychresns.2015.01.022
BibTex
@article{Israel2015-04nBack-38478,
  year={2015},
  doi={10.1016/j.pscychresns.2015.01.022},
  title={n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings},
  number={1},
  volume={232},
  issn={0925-4927},
  journal={Psychiatry Research : Neuroimaging},
  pages={84--91},
  author={Israel, Mimi and Klein, Michael and Pruessner, Jens C. and Thaler, Lea and Spilka, Michael and Efanov, Simona and Ouellette, Anne-Sophie and Berlim, Marcelo and Ali, Nida and Steiger, Howard}
}
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