n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings
n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings
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Date
2015
Authors
Israel, Mimi
Klein, Michael
Thaler, Lea
Spilka, Michael
Efanov, Simona
Ouellette, Anne-Sophie
Berlim, Marcelo
Ali, Nida
Steiger, Howard
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Psychiatry Research : Neuroimaging ; 232 (2015), 1. - pp. 84-91. - ISSN 0925-4927. - eISSN 1872-7123
Abstract
Eating disorder (ED) variants characterized by "binge-eating/purging" symptoms differ from "restricting-only" variants along diverse clinical dimensions, but few studies have compared people with these different eating-disorder phenotypes on measures of neurocognitive function and brain activation. We tested the performances of 19 women with "restricting-only" eating syndromes and 27 with "binge-eating/purging" variants on a modified n-back task, and used functional magnetic resonance imaging (fMRI) to examine task-induced brain activations in frontal regions of interest. When compared with "binge-eating/purging" participants, "restricting-only" participants showed superior performance. Furthermore, in an intermediate-demand condition, "binge-eating/purging" participants showed significantly less event-related activation than did "restricting-only" participants in a right posterior prefrontal region spanning Brodmann areas 6-8-a region that has been linked to planning of motor responses, working memory for sequential information, and management of uncertainty. Our findings suggest that working memory is poorer in eating-disordered individuals with binge-eating/purging behaviors than in those who solely restrict food intake, and that observed performance differences coincide with interpretable group-based activation differences in a frontal region thought to subserve planning and decision making.
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150 Psychology
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Eating disorders; Functional neuroimaging; Executive function; Anorexia; Bulimia; Binge eating
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ISRAEL, Mimi, Michael KLEIN, Jens C. PRUESSNER, Lea THALER, Michael SPILKA, Simona EFANOV, Anne-Sophie OUELLETTE, Marcelo BERLIM, Nida ALI, Howard STEIGER, 2015. n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings. In: Psychiatry Research : Neuroimaging. 232(1), pp. 84-91. ISSN 0925-4927. eISSN 1872-7123. Available under: doi: 10.1016/j.pscychresns.2015.01.022BibTex
@article{Israel2015-04nBack-38478, year={2015}, doi={10.1016/j.pscychresns.2015.01.022}, title={n-Back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants : Preliminary findings}, number={1}, volume={232}, issn={0925-4927}, journal={Psychiatry Research : Neuroimaging}, pages={84--91}, author={Israel, Mimi and Klein, Michael and Pruessner, Jens C. and Thaler, Lea and Spilka, Michael and Efanov, Simona and Ouellette, Anne-Sophie and Berlim, Marcelo and Ali, Nida and Steiger, Howard} }
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