Energy conservation in the decarboxylation of dicarboxylic acids by fermenting bacteria

Dimroth, Peter; Schink, Bernhard

Energy conservation in the decarboxylation of dicarboxylic acids by fermenting bacteria

Files

Energy_conservation_in_the_decarboxylation_of_dicarboxylic_acids_by_fermenting_bacteria.pdf(171.89 KB)

Date

1998

Authors

Dimroth, Peter

Schink, Bernhard

Publication type

Journal article

Published in

Archives of microbiology ; 170 (1998), 2. - pp. 69-77. - ISSN 0302-8933. - eISSN 1432-072X

Abstract

Decarboxylation of dicarboxylic acids (oxalate, malonate, succinate, glutarate, and malate) can serve as the sole energy source for the growth of fermenting bacteria. Since the free energy change of a decarboxylation reaction is small (around 20 kJ per mol) and equivalent to only approximately one-third of the energy required for ATP synthesis from ADP and phosphate under physiological conditions, the decarboxylation energy cannot be conserved by substrate-level phosphorylation. It is either converted (in malonate, succinate, and glutarate fermentation) by membrane-bound primary decarboxylase sodium ion pumps into an electrochemical gradient of sodium ions across the membrane; or, alternatively, an electrochemical proton gradient can be established by the combined action of a soluble decarboxylase with a dicarboxylate/monocarboxylate antiporter (in oxalate and malate fermentation). The thus generated electrochemical Na+ or H+ gradients are then exploited for ATP synthesis by Na+- or H+-coupled F1F0 ATP synthases. This new type of energy conservation has been termed decarboxylation phosphorylation and is responsible entirely for ATP synthesis in several anaerobic bacteria.

Subject (DDC)

570 Biosciences, Biology

Keywords

ATP synthase,decarboxylation,electrogenic substrate/product antiporter,sodium ion pump,Malo-lactic fermentation,Oxalate,Malonate

Cite This

ISO 690

DIMROTH, Peter, Bernhard SCHINK, 1998. Energy conservation in the decarboxylation of dicarboxylic acids by fermenting bacteria. In: Archives of microbiology. 170(2), pp. 69-77. ISSN 0302-8933. eISSN 1432-072X. Available under: doi: 10.1007/s002030050616

BibTex

@article{Dimroth1998Energ-8202,
  year={1998},
  doi={10.1007/s002030050616},
  title={Energy conservation in the decarboxylation of dicarboxylic acids by fermenting bacteria},
  number={2},
  volume={170},
  issn={0302-8933},
  journal={Archives of microbiology},
  pages={69--77},
  author={Dimroth, Peter and Schink, Bernhard}
}

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