@article{Camenisch2009Twost-979,
  year={2009},
  doi={10.1038/emboj.2009.187},
  title={Two-stage dynamic DNA quality check by Xeroderma Pigmentosum group C protein},
  number={16},
  volume={28},
  issn={0261-4189},
  journal={The EMBO Journal},
  pages={2387--2399},
  author={Camenisch, Ulrike and Träutlein, Daniel and Clement, Flurina C. and Fei, Jia and Leitenstorfer, Alfred and Ferrando-May, Elisa and Naegeli, Hanspeter}
}

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    <dc:contributor>Camenisch, Ulrike</dc:contributor>
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    <dc:contributor>Fei, Jia</dc:contributor>
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    <dc:contributor>Ferrando-May, Elisa</dc:contributor>
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    <dc:creator>Träutlein, Daniel</dc:creator>
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    <dcterms:abstract xml:lang="eng">Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix-distorting base lesions. To understand how this versatile subunit searches for aberrant sites within the vast background of normal genomic DNA, the real-time redistribution of fluorescent fusion constructs was monitored after high-resolution DNA damage induction. Bidirectional truncation analyses disclosed a surprisingly short recognition hotspot, comprising approx15% of human XPC, that includes two beta-hairpin domains with a preference for non-hydrogen-bonded bases in double-stranded DNA. However, to detect damaged sites in living cells, these DNA-attractive domains depend on the partially DNA-repulsive action of an adjacent beta-turn extension that promotes the mobility of XPC molecules searching for lesions. The key function of this dynamic interaction surface is shown by a site-directed charge inversion, which results in increased affinity for native DNA, retarded nuclear mobility and diminished repair efficiency. These studies reveal a two-stage discrimination process, whereby XPC protein first deploys a dynamic sensor interface to rapidly interrogate the double helix, thus forming a transient recognition intermediate before the final installation of a more static repair-initiating complex.</dcterms:abstract>
    <dc:creator>Fei, Jia</dc:creator>
    <dc:creator>Leitenstorfer, Alfred</dc:creator>
    <dc:creator>Naegeli, Hanspeter</dc:creator>
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    <dc:contributor>Naegeli, Hanspeter</dc:contributor>
    <dc:contributor>Clement, Flurina C.</dc:contributor>
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    <dc:creator>Clement, Flurina C.</dc:creator>
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    <dcterms:title>Two-stage dynamic DNA quality check by Xeroderma Pigmentosum group C protein</dcterms:title>
    <dcterms:bibliographicCitation>First publ. in: The EMBO Journal ; 28 (2009), 16. -  pp. 2387-2399</dcterms:bibliographicCitation>
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