Human Hippocampal Dynamics during Response Conflict

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2015
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Oehrn, Carina R.
Baumann, Conrad
Fell, Juergen
Lee, Hweeling
Kessler, Henrik
Habel, Ute
Axmacher, Nikolai
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Current Biology. 2015, 25(17), pp. 2307-2313. ISSN 0960-9822. eISSN 1879-0445. Available under: doi: 10.1016/j.cub.2015.07.032
Zusammenfassung

Besides its relevance for declarative memory functions, hippocampal activation has been observed during disambiguation of uncertainty and conflict. Uncertainty and conflict may arise on various levels. On the perceptual level, the hippocampus has been associated with signaling of contextual deviance and disambiguation of similar items (i.e., pattern separation). Furthermore, conflicts can occur on the response level. Animal experiments showed a role of the hippocampus for inhibition of prevailing response tendencies and suppression of automatic stimulus-response mappings, potentially related to increased theta oscillations (3-8 Hz). In humans, a recent fMRI study demonstrated hippocampal involvement in approach-avoidance conflicts. However, the more general significance of hippocampal activity for dealing with response conflicts also on a cognitive level is still unknown. Here, we investigated the role of the hippocampus for response conflict in the Stroop task by combining intracranial electroencephalography (iEEG) recordings from the hippocampus of epilepsy patients with region of interest-based fMRI in healthy participants. Both methods revealed converging evidence that the hippocampus is recruited in a regionally specific manner during response conflict. Moreover, our iEEG data show that this activation depends on theta oscillations and is relevant for successful response conflict resolution.

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ISO 690OEHRN, Carina R., Conrad BAUMANN, Juergen FELL, Hweeling LEE, Henrik KESSLER, Ute HABEL, Simon HANSLMAYR, Nikolai AXMACHER, 2015. Human Hippocampal Dynamics during Response Conflict. In: Current Biology. 2015, 25(17), pp. 2307-2313. ISSN 0960-9822. eISSN 1879-0445. Available under: doi: 10.1016/j.cub.2015.07.032
BibTex
@article{Oehrn2015Human-32920,
  year={2015},
  doi={10.1016/j.cub.2015.07.032},
  title={Human Hippocampal Dynamics during Response Conflict},
  number={17},
  volume={25},
  issn={0960-9822},
  journal={Current Biology},
  pages={2307--2313},
  author={Oehrn, Carina R. and Baumann, Conrad and Fell, Juergen and Lee, Hweeling and Kessler, Henrik and Habel, Ute and Hanslmayr, Simon and Axmacher, Nikolai}
}
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