Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances
Lade...
Dateien
Datum
2009
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
The International Journal of Biochemistry & Cell Biology. 2009, 42(2), pp. 198-201. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2009.09.015
Zusammenfassung
Prostaglandin E2 (PGE2) is the most abundant eicosanoid and a very potent lipid mediator. PGE2 is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE2 acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE2 is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE2 synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE2 receptor antagonism is of great therapeutic interest.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
LEGLER, Daniel F., Markus BRUCKNER, Edith UETZ-ALLMEN, Petra KRAUSE, 2009. Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances. In: The International Journal of Biochemistry & Cell Biology. 2009, 42(2), pp. 198-201. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2009.09.015BibTex
@article{Legler2009Prost-3303,
year={2009},
doi={10.1016/j.biocel.2009.09.015},
title={Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances},
number={2},
volume={42},
issn={1357-2725},
journal={The International Journal of Biochemistry & Cell Biology},
pages={198--201},
author={Legler, Daniel F. and Bruckner, Markus and Uetz-Allmen, Edith and Krause, Petra}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/3303">
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
<dcterms:bibliographicCitation>Publ. in: The International Journal of Biochemistry & Cell Biology 42 (2010), 2, pp. 198-201</dcterms:bibliographicCitation>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T10:19:58Z</dc:date>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/3303"/>
<dcterms:title>Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances</dcterms:title>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T10:19:58Z</dcterms:available>
<dc:creator>Krause, Petra</dc:creator>
<dc:contributor>Bruckner, Markus</dc:contributor>
<dc:contributor>Krause, Petra</dc:contributor>
<dc:rights>terms-of-use</dc:rights>
<dcterms:abstract xml:lang="deu">Prostaglandin E2 (PGE2) is the most abundant eicosanoid and a very potent lipid mediator. PGE2 is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE2 acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE2 is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE2 synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE2 receptor antagonism is of great therapeutic interest.</dcterms:abstract>
<dc:language>eng</dc:language>
<dc:contributor>Uetz-Allmen, Edith</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/3303/1/Legler_opus-106237.pdf"/>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:creator>Bruckner, Markus</dc:creator>
<dc:creator>Legler, Daniel F.</dc:creator>
<dcterms:issued>2009</dcterms:issued>
<dc:creator>Uetz-Allmen, Edith</dc:creator>
<dc:contributor>Legler, Daniel F.</dc:contributor>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/3303/1/Legler_opus-106237.pdf"/>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
</rdf:Description>
</rdf:RDF>
