Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances

Lade...
Vorschaubild
Dateien
Legler_opus-106237.pdf
Legler_opus-106237.pdfGröße: 224.92 KBDownloads: 707
Datum
2009
Autor:innen
Bruckner, Markus
Uetz-Allmen, Edith
Krause, Petra
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Prostaglandin E2 (PGE2) is the most abundant eicosanoid and a very potent lipid mediator. PGE2 is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE2 acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE2 is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE2 synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE2 receptor antagonism is of great therapeutic interest.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690LEGLER, Daniel F., Markus BRUCKNER, Edith UETZ-ALLMEN, Petra KRAUSE, 2009. Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances. In: The International Journal of Biochemistry & Cell Biology. 2009, 42(2), pp. 198-201. ISSN 1357-2725. eISSN 1878-5875. Available under: doi: 10.1016/j.biocel.2009.09.015
BibTex
@article{Legler2009Prost-3303,
  year={2009},
  doi={10.1016/j.biocel.2009.09.015},
  title={Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances},
  number={2},
  volume={42},
  issn={1357-2725},
  journal={The International Journal of Biochemistry & Cell Biology},
  pages={198--201},
  author={Legler, Daniel F. and Bruckner, Markus and Uetz-Allmen, Edith and Krause, Petra}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/3303">
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:bibliographicCitation>Publ. in: The International Journal of Biochemistry &amp; Cell Biology 42 (2010), 2, pp. 198-201</dcterms:bibliographicCitation>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T10:19:58Z</dc:date>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/3303"/>
    <dcterms:title>Prostaglandin E(2) at new glance : Novel insights in functional diversity offer therapeutic chances</dcterms:title>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T10:19:58Z</dcterms:available>
    <dc:creator>Krause, Petra</dc:creator>
    <dc:contributor>Bruckner, Markus</dc:contributor>
    <dc:contributor>Krause, Petra</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:abstract xml:lang="deu">Prostaglandin E2 (PGE2) is the most abundant eicosanoid and a very potent lipid mediator. PGE2 is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE2  acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE2 is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE2 synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE2 receptor antagonism is of great therapeutic interest.</dcterms:abstract>
    <dc:language>eng</dc:language>
    <dc:contributor>Uetz-Allmen, Edith</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/3303/1/Legler_opus-106237.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Bruckner, Markus</dc:creator>
    <dc:creator>Legler, Daniel F.</dc:creator>
    <dcterms:issued>2009</dcterms:issued>
    <dc:creator>Uetz-Allmen, Edith</dc:creator>
    <dc:contributor>Legler, Daniel F.</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/3303/1/Legler_opus-106237.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Begutachtet
Diese Publikation teilen