@article{Dogan2008-12Xlink-38710,
  year={2008},
  doi={10.1038/ncb1804},
  title={X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility},
  number={12},
  volume={10},
  issn={1465-7392},
  journal={Nature cell biology},
  pages={1447--1455},
  author={Dogan, Taner and Harms, Gregory S. and Hekman, Mirko and Karreman, Christiaan and Oberoi, Tripat Kaur and Alnemri, Emad S. and Rapp, Ulf R. and Rajalingam, Krishnaraj},
  note={There is an Erratum (January 2009) associated with this Article : Nature Cell Biology 11, 110 (2009), http://dx.doi.org/10.1038/ncb0109-110}
}

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    <dc:creator>Rapp, Ulf R.</dc:creator>
    <dc:contributor>Hekman, Mirko</dc:contributor>
    <dc:contributor>Rapp, Ulf R.</dc:contributor>
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    <dc:creator>Karreman, Christiaan</dc:creator>
    <dc:contributor>Dogan, Taner</dc:contributor>
    <dc:creator>Hekman, Mirko</dc:creator>
    <dc:contributor>Oberoi, Tripat Kaur</dc:contributor>
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    <dc:creator>Dogan, Taner</dc:creator>
    <dc:creator>Rajalingam, Krishnaraj</dc:creator>
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    <dcterms:abstract xml:lang="eng">Inhibitor of apoptosis proteins (IAP) are evolutionarily conserved anti-apoptotic regulators. C-RAF protein kinase is a direct RAS effector protein, which initiates the classical mitogen-activated protein kinase (MAPK) cascade. This signalling cascade mediates diverse biological functions, such as cell growth, proliferation, migration, differentiation and survival. Here we demonstrate that XIAP and c-IAPs bind directly to C-RAF kinase and that siRNA-mediated silencing of XIAP and c-IAPs leads to stabilization of C-RAF in human cells. XIAP binds strongly to C-RAF and promotes the ubiquitylation of C-RAF in vivo through the Hsp90-mediated quality control system, independently of its E3 ligase activity. In addition, XIAP or c-IAP-1/2 knockdown cells showed enhanced cell migration in a C-RAF-dependent manner. XIAP promotes binding of CHIP (carboxy terminal Hsc70-interacting protein), a chaperone-associated ubiquitin ligase, to the C-RAF-Hsp90 complex in vivo. Interfering with CHIP expression resulted in stabilization of C-RAF and enhanced cell migration, as observed in XIAP knockdown cells. Our data show an unexpected role of XIAP and c-IAPs in the turnover of C-RAF protein, thereby modulating the MAPK signalling pathway and cell migration.</dcterms:abstract>
    <dcterms:issued>2008-12</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-04T07:30:05Z</dc:date>
    <dc:contributor>Rajalingam, Krishnaraj</dc:contributor>
    <dc:contributor>Karreman, Christiaan</dc:contributor>
    <dc:contributor>Harms, Gregory S.</dc:contributor>
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    <dc:contributor>Alnemri, Emad S.</dc:contributor>
    <dcterms:title>X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility</dcterms:title>
    <dc:creator>Harms, Gregory S.</dc:creator>
    <dc:creator>Oberoi, Tripat Kaur</dc:creator>
    <dc:creator>Alnemri, Emad S.</dc:creator>
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