rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?
| dc.contributor.author | Liebau, Christian | |
| dc.contributor.author | Merk, Harry | |
| dc.contributor.author | Roesel, Christian | |
| dc.contributor.author | Schmidt, Sebastian | |
| dc.contributor.author | Karreman, Christiaan | |
| dc.contributor.author | Prisack, Johannes Bernd | |
| dc.contributor.author | Bojar, Hans | |
| dc.contributor.author | Baltzer, Axel W. A. | |
| dc.date.accessioned | 2017-05-09T11:11:11Z | |
| dc.date.available | 2017-05-09T11:11:11Z | |
| dc.date.issued | 2002 | eng |
| dc.description.abstract | Gene therapy is a promising new method to treat tumors locally. Immuno-therapy for treatment of osteosarcomas is one option for hopefully improving the survival rate of patients with this tumor. Transduction of OS cells with the pCMV-IL-12neo plasmid induced a significant increase in IFN-gamma expression by mononuclear cells. This is known to induce antitumor effects mediated by the immune system. In combination with an administration of rIL-18, the IFN-gamma increase was multiplied in a dose-dependent manner. This study demonstrated that osteosarcoma cells can be targeted effectively in vitro by plasmids encoding the IL-12 gene. Considering the synergistic pathways it is reasonable to combine a local, gene transfer based on IL-12 with a rIL-18 administration to trigger the potentially promising immuno-effects for adjuvant treatment of osteosarcomas. | eng |
| dc.description.version | published | eng |
| dc.identifier.pmid | 12529964 | eng |
| dc.identifier.uri | https://kops.uni-konstanz.de/handle/123456789/38814 | |
| dc.language.iso | eng | eng |
| dc.subject.ddc | 570 | eng |
| dc.title | rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma? | eng |
| dc.type | JOURNAL_ARTICLE | eng |
| dspace.entity.type | Publication | |
| kops.citation.bibtex | @article{Liebau2002rIL18-38814,
year={2002},
title={rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?},
number={5},
volume={22},
issn={0250-7005},
journal={Anticancer Research},
pages={2559--2565},
author={Liebau, Christian and Merk, Harry and Roesel, Christian and Schmidt, Sebastian and Karreman, Christiaan and Prisack, Johannes Bernd and Bojar, Hans and Baltzer, Axel W. A.}
} | |
| kops.citation.iso690 | LIEBAU, Christian, Harry MERK, Christian ROESEL, Sebastian SCHMIDT, Christiaan KARREMAN, Johannes Bernd PRISACK, Hans BOJAR, Axel W. A. BALTZER, 2002. rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?. In: Anticancer Research. 2002, 22(5), pp. 2559-2565. ISSN 0250-7005. eISSN 1791-7530 | deu |
| kops.citation.iso690 | LIEBAU, Christian, Harry MERK, Christian ROESEL, Sebastian SCHMIDT, Christiaan KARREMAN, Johannes Bernd PRISACK, Hans BOJAR, Axel W. A. BALTZER, 2002. rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?. In: Anticancer Research. 2002, 22(5), pp. 2559-2565. ISSN 0250-7005. eISSN 1791-7530 | eng |
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<dcterms:abstract xml:lang="eng">Gene therapy is a promising new method to treat tumors locally. Immuno-therapy for treatment of osteosarcomas is one option for hopefully improving the survival rate of patients with this tumor. Transduction of OS cells with the pCMV-IL-12neo plasmid induced a significant increase in IFN-gamma expression by mononuclear cells. This is known to induce antitumor effects mediated by the immune system. In combination with an administration of rIL-18, the IFN-gamma increase was multiplied in a dose-dependent manner. This study demonstrated that osteosarcoma cells can be targeted effectively in vitro by plasmids encoding the IL-12 gene. Considering the synergistic pathways it is reasonable to combine a local, gene transfer based on IL-12 with a rIL-18 administration to trigger the potentially promising immuno-effects for adjuvant treatment of osteosarcomas.</dcterms:abstract>
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