Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice

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1998
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Steinbach, Joachim P.
Müller, Ulrike
Li, Zhi-Wei
Aguzzi, Adriano
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Journal of Cell Death and Differentiation. 1998, 5(10), pp. 858-866
Zusammenfassung

Secreted forms of the β-amyloid precursor protein (β-APP) have neuroprotective properties in vitro and may be involved in the containment of neuronal excitation. To test whether loss of secreted forms of β-APP (sAPPs) may enhance excitotoxic responses, we injected mice homozygous for a targeted mutation of the β-APP gene (β-APP∆/∆) intraperitoneally with kainic acid. We found that in these mice, kainic acid induced seizures initiated earlier, and acute mortality was enhanced compared to isogenic wild-type mice independently from the callosal agenesis phenotype observed to occur at increased frequency in APP mutant mice. Expression of c-fos in cortex and cingulate gyrus was enhanced in β-APP∆/∆ mice, although the amount of structural damage and apoptosis in the hippocampal pyramidal cell layer and cortex was similar to that of controls. When cerebellar granule cell cultures and cortical neuronal cultures were challenged with glutamate receptor agonists, the rates of cell death and apoptosis of β-APP∆/∆ mice were indistinguishable from those of controls. Therefore, deficiency of sAPPs causes facilitation of seizure activity in the absence of enhanced cell death. Since enhanced seizures were observed also in mice homozygous for a deletion of the entire β-APP gene, this phenotype results from a loss of APP rather than from a dominant effect of APP∆.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Alzheimer's disease, β-amyloid precursor protein, β- APP deficient mice, kainic acid, neuronal cultures, excitotoxicity c-fos, apoptosis
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ISO 690STEINBACH, Joachim P., Ulrike MÜLLER, Marcel LEIST, Zhi-Wei LI, Pierluigi NICOTERA, Adriano AGUZZI, 1998. Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice. In: Journal of Cell Death and Differentiation. 1998, 5(10), pp. 858-866
BibTex
@article{Steinbach1998Hyper-8115,
  year={1998},
  title={Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice},
  number={10},
  volume={5},
  journal={Journal of Cell Death and Differentiation},
  pages={858--866},
  author={Steinbach, Joachim P. and Müller, Ulrike and Leist, Marcel and Li, Zhi-Wei and Nicotera, Pierluigi and Aguzzi, Adriano}
}
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