Bacterial DNAemia in older subjects and nonagenarian offspring and association with redox biomarkers : results from MARK-AGE Study

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2023
Autor:innen
Giacconi, Robertina
D'Aquila, Patrizia
Malavolta, Marco
Piacenza, Francesco
Dollé, Martijn E T
Jansen, Eugène
Bellizzi, Dina
Provinciali, Mauro
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European Union (EU): 200880
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MARK-AGE: European study to establish biomarkers of human ageing
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Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Oxford University Press (OUP). 2023, 78(1), pp. 42-50. ISSN 1079-5006. eISSN 1758-535X. Available under: doi: 10.1093/gerona/glac154
Zusammenfassung

Aging and age-related diseases have been linked to microbial dysbiosis with changes in blood bacterial DNA concentration. This condition may promote chronic low-grade inflammation, which can be further aggravated by antioxidant nutrient deficiency. Low plasma carotenoids are associated with an increased risk of inflammation and cellular damage and predict mortality. However, no evidence is yet available on the relationship between antioxidants and the blood bacterial DNA (BB-DNA). Therefore, this study aimed to compare BB-DNA from (i) GO (nonagenarian offspring), (ii) age matched controls [(Randomly recruited Age-Stratified Individuals from the General population (RASIG)] and (iii) Spouses of GO (SGO) recruited in the MARK-AGE project, as well as to investigate the association between BB-DNA, behavior habits, Charlson comorbidity index (CCI), leucocyte subsets, and the circulating levels of some antioxidants and oxidative stress markers.

BB-DNA was higher in RASIG than GO and SGO, while GO and SGO participants showed similar values. BB-DNA increased in smokers and in males with CCI≥2 compared to those with CCI≤1 within RASIG. Moreover, BB-DNA was positively associated with lymphocyte, neutrophil and monocyte counts, but not with self-reported dietary habits. Higher quartiles of BB-DNA were associated with low lutein and zeaxanthin and elevated malondialdehyde plasma concentrations in RASIG. BB-DNA was also positively correlated with nitric oxide levels.

Herein, we provide evidence of a reduced BB-DNA in individuals from long-living families and their spouses, suggesting a decreased microbial dysbiosis and bacterial systemic translocation. BB-DNA was also associated with smoking, CCI, leukocyte subsets and some redox biomarkers in older subjects.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
blood bacterial DNA, longevity, aging, inflammation, dysbiosis
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ISO 690GIACCONI, Robertina, Patrizia D'AQUILA, Marco MALAVOLTA, Francesco PIACENZA, Alexander BÜRKLE, Maria MORENO-VILLANUEVA, Martijn E T DOLLÉ, Eugène JANSEN, Dina BELLIZZI, Mauro PROVINCIALI, 2023. Bacterial DNAemia in older subjects and nonagenarian offspring and association with redox biomarkers : results from MARK-AGE Study. In: Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Oxford University Press (OUP). 2023, 78(1), pp. 42-50. ISSN 1079-5006. eISSN 1758-535X. Available under: doi: 10.1093/gerona/glac154
BibTex
@article{Giacconi2023Bacte-58245,
  year={2023},
  doi={10.1093/gerona/glac154},
  title={Bacterial DNAemia in older subjects and nonagenarian offspring and association with redox biomarkers : results from MARK-AGE Study},
  number={1},
  volume={78},
  issn={1079-5006},
  journal={Journals of Gerontology Series A: Biological Sciences and Medical Sciences},
  pages={42--50},
  author={Giacconi, Robertina and D'Aquila, Patrizia and Malavolta, Marco and Piacenza, Francesco and Bürkle, Alexander and Moreno-Villanueva, Maria and Dollé, Martijn E T and Jansen, Eugène and Bellizzi, Dina and Provinciali, Mauro}
}
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