@article{DiGiovanni2020-02-28Gluta-56831,
  year={2020},
  doi={10.3390/ijms21051638},
  title={Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair},
  number={5},
  volume={21},
  issn={1661-6596},
  journal={International Journal of Molecular Sciences},
  author={Di Giovanni, Emilia and Buonvino, Silvia and Amelio, Ivano and Melino, Sonia},
  note={Article Number: 1638}
}

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    <dc:creator>Di Giovanni, Emilia</dc:creator>
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    <dcterms:title>Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair</dcterms:title>
    <dcterms:abstract xml:lang="eng">The endogenous gasotransmitter H&lt;sub&gt;2&lt;/sub&gt;S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H&lt;sub&gt;2&lt;/sub&gt;S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for cardiovascular and neurodegenerative diseases. Nonetheless, the effects of H&lt;sub&gt;2&lt;/sub&gt;S-releasing agents on the growth of stem cells have not been fully investigated. H&lt;sub&gt;2&lt;/sub&gt;S preconditioning can enhance mesenchymal stem cell survival after post-ischaemic myocardial implantation; therefore, stem cell therapy combined with H&lt;sub&gt;2&lt;/sub&gt;S may be relevant in cell-based therapy for regenerative medicine. Here, we studied the effects of slow-releasing H&lt;sub&gt;2&lt;/sub&gt;S agents on the cell growth and differentiation of cardiac Lin&lt;sup&gt;-&lt;/sup&gt; Sca1&lt;sup&gt;+&lt;/sup&gt; human mesenchymal stem cells (cMSC) and on normal human dermal fibroblasts (NHDF). In particular, we investigated the effects of water-soluble GSH-garlic conjugates (GSGa) on cMSC compared to other H&lt;sub&gt;2&lt;/sub&gt;S-releasing agents, such as Na&lt;sub&gt;2&lt;/sub&gt;S and GYY4137. GSGa treatment of cMSC and NHDF increased their cell proliferation and migration in a concentration dependent manner with respect to the control. GSGa treatment promoted an upregulation of the expression of proteins involved in oxidative stress protection, cell-cell adhesion and commitment to differentiation. These results highlight the effects of H&lt;sub&gt;2&lt;/sub&gt;S-natural donors as biochemical factors that promote MSC homing, increasing their safety profile and efficacy after transplantation, and the value of these donors in developing functional 3D-stem cell delivery systems for cardiac muscle tissue repair and regeneration.</dcterms:abstract>
    <dc:creator>Buonvino, Silvia</dc:creator>
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    <dc:contributor>Buonvino, Silvia</dc:contributor>
    <dc:contributor>Amelio, Ivano</dc:contributor>
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    <dcterms:issued>2020-02-28</dcterms:issued>
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    <dc:creator>Amelio, Ivano</dc:creator>
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    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:contributor>Di Giovanni, Emilia</dc:contributor>
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    <dc:creator>Melino, Sonia</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-11T10:17:52Z</dc:date>
    <dc:contributor>Melino, Sonia</dc:contributor>
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