Amygdala habituation : a reliable fMRI phenotype

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2014
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Plichta, Michael M.
Grimm, Oliver
Morgen, Katrin
Sauer, Carina
Haddad, Leila
Tost, Heike
Esslinger, Christine
Kirsch, Peter
Schwarz, Adam J.
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NeuroImage. 2014, 103, pp. 383-390. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2014.09.059
Zusammenfassung

Amygdala function is of high interest for cognitive, social and psychiatric neuroscience, emphasizing the need for reliable assessments in humans. Previous work has indicated unsatisfactorily low within-subject reliability of amygdala activation fMRI measures. Based on basic science evidence for strong habituation of amygdala response to repeated stimuli, we investigated whether a quantification of habituation provides additional information beyond the usual estimate of the overall mean activity. We assessed the within-subject reliability of amygdala habituation measures during a facial emotion matching paradigm in 25 healthy subjects. We extracted the amygdala signal decrement across the course of the fMRI run for the two test-retest measurement sessions and compared reliability estimates with previous findings based on mean response amplitude. Retest-reliability of the session-wise amygdala habituation was significantly higher than the evoked amygdala mean amplitude (intraclass correlation coefficients (ICC)=0.53 vs. 0.16). To test the task-specificity of this finding, we compared the retest-reliability of amygdala habituation across two different tasks. Significant amygdala response decrement was also seen in a cognitive task (n-back working memory) that did not per se activate the amygdala, but was totally unreliable in that context (ICC~0.0), arguing for task-specificity. Together the results show that emotion-dependent amygdala habituation is a robust and considerably more reliable index than the mean amplitude, and provides a robust potential endpoint for within-subject designs including pharmaco-fMRI studies.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Amygdala habituation, fMRI, Retest reliability, Intra-class correlation coefficient (ICC), Emotion, Faces
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ISO 690PLICHTA, Michael M., Oliver GRIMM, Katrin MORGEN, Daniela MIER, Carina SAUER, Leila HADDAD, Heike TOST, Christine ESSLINGER, Peter KIRSCH, Adam J. SCHWARZ, 2014. Amygdala habituation : a reliable fMRI phenotype. In: NeuroImage. 2014, 103, pp. 383-390. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2014.09.059
BibTex
@article{Plichta2014-12Amygd-45881,
  year={2014},
  doi={10.1016/j.neuroimage.2014.09.059},
  title={Amygdala habituation : a reliable fMRI phenotype},
  volume={103},
  issn={1053-8119},
  journal={NeuroImage},
  pages={383--390},
  author={Plichta, Michael M. and Grimm, Oliver and Morgen, Katrin and Mier, Daniela and Sauer, Carina and Haddad, Leila and Tost, Heike and Esslinger, Christine and Kirsch, Peter and Schwarz, Adam J.}
}
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