Amygdala habituation : a reliable fMRI phenotype

Plichta, Michael M.; Grimm, Oliver; Morgen, Katrin; Mier, Daniela; Sauer, Carina; Haddad, Leila; Tost, Heike; Esslinger, Christine; Kirsch, Peter; Schwarz, Adam J.

Amygdala habituation : a reliable fMRI phenotype

Dateien

Plichta_2-ahwyeetv9kci8.pdfGröße: 726.29 KBDownloads: 248

Datum

2014

Autor:innen

Plichta, Michael M.

Grimm, Oliver

Morgen, Katrin

Mier, Daniela

Sauer, Carina

Haddad, Leila

Tost, Heike

Esslinger, Christine

Kirsch, Peter

Schwarz, Adam J.

et al.

Open Access-Veröffentlichung

Open Access Hybrid

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

NeuroImage. 2014, 103, pp. 383-390. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2014.09.059

Zusammenfassung

Amygdala function is of high interest for cognitive, social and psychiatric neuroscience, emphasizing the need for reliable assessments in humans. Previous work has indicated unsatisfactorily low within-subject reliability of amygdala activation fMRI measures. Based on basic science evidence for strong habituation of amygdala response to repeated stimuli, we investigated whether a quantification of habituation provides additional information beyond the usual estimate of the overall mean activity. We assessed the within-subject reliability of amygdala habituation measures during a facial emotion matching paradigm in 25 healthy subjects. We extracted the amygdala signal decrement across the course of the fMRI run for the two test-retest measurement sessions and compared reliability estimates with previous findings based on mean response amplitude. Retest-reliability of the session-wise amygdala habituation was significantly higher than the evoked amygdala mean amplitude (intraclass correlation coefficients (ICC)=0.53 vs. 0.16). To test the task-specificity of this finding, we compared the retest-reliability of amygdala habituation across two different tasks. Significant amygdala response decrement was also seen in a cognitive task (n-back working memory) that did not per se activate the amygdala, but was totally unreliable in that context (ICC~0.0), arguing for task-specificity. Together the results show that emotion-dependent amygdala habituation is a robust and considerably more reliable index than the mean amplitude, and provides a robust potential endpoint for within-subject designs including pharmaco-fMRI studies.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Amygdala habituation, fMRI, Retest reliability, Intra-class correlation coefficient (ICC), Emotion, Faces

Zitieren

ISO 690

PLICHTA, Michael M., Oliver GRIMM, Katrin MORGEN, Daniela MIER, Carina SAUER, Leila HADDAD, Heike TOST, Christine ESSLINGER, Peter KIRSCH, Adam J. SCHWARZ, 2014. Amygdala habituation : a reliable fMRI phenotype. In: NeuroImage. 2014, 103, pp. 383-390. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2014.09.059

BibTex

@article{Plichta2014-12Amygd-45881,
  year={2014},
  doi={10.1016/j.neuroimage.2014.09.059},
  title={Amygdala habituation : a reliable fMRI phenotype},
  volume={103},
  issn={1053-8119},
  journal={NeuroImage},
  pages={383--390},
  author={Plichta, Michael M. and Grimm, Oliver and Morgen, Katrin and Mier, Daniela and Sauer, Carina and Haddad, Leila and Tost, Heike and Esslinger, Christine and Kirsch, Peter and Schwarz, Adam J.}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/45881">
    <dc:creator>Mier, Daniela</dc:creator>
    <dc:contributor>Morgen, Katrin</dc:contributor>
    <dc:creator>Schwarz, Adam J.</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-05-22T13:25:02Z</dcterms:available>
    <dcterms:title>Amygdala habituation : a reliable fMRI phenotype</dcterms:title>
    <dc:creator>Kirsch, Peter</dc:creator>
    <dc:contributor>Sauer, Carina</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Grimm, Oliver</dc:contributor>
    <dc:contributor>Mier, Daniela</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/45881/1/Plichta_2-ahwyeetv9kci8.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/45881/1/Plichta_2-ahwyeetv9kci8.pdf"/>
    <dc:creator>Haddad, Leila</dc:creator>
    <dc:contributor>Haddad, Leila</dc:contributor>
    <dc:creator>Sauer, Carina</dc:creator>
    <dcterms:issued>2014-12</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-05-22T13:25:02Z</dc:date>
    <dc:creator>Plichta, Michael M.</dc:creator>
    <dc:contributor>Plichta, Michael M.</dc:contributor>
    <dcterms:abstract xml:lang="eng">Amygdala function is of high interest for cognitive, social and psychiatric neuroscience, emphasizing the need for reliable assessments in humans. Previous work has indicated unsatisfactorily low within-subject reliability of amygdala activation fMRI measures. Based on basic science evidence for strong habituation of amygdala response to repeated stimuli, we investigated whether a quantification of habituation provides additional information beyond the usual estimate of the overall mean activity. We assessed the within-subject reliability of amygdala habituation measures during a facial emotion matching paradigm in 25 healthy subjects. We extracted the amygdala signal decrement across the course of the fMRI run for the two test-retest measurement sessions and compared reliability estimates with previous findings based on mean response amplitude. Retest-reliability of the session-wise amygdala habituation was significantly higher than the evoked amygdala mean amplitude (intraclass correlation coefficients (ICC)=0.53 vs. 0.16). To test the task-specificity of this finding, we compared the retest-reliability of amygdala habituation across two different tasks. Significant amygdala response decrement was also seen in a cognitive task (n-back working memory) that did not per se activate the amygdala, but was totally unreliable in that context (ICC~0.0), arguing for task-specificity. Together the results show that emotion-dependent amygdala habituation is a robust and considerably more reliable index than the mean amplitude, and provides a robust potential endpoint for within-subject designs including pharmaco-fMRI studies.</dcterms:abstract>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:contributor>Kirsch, Peter</dc:contributor>
    <dc:rights>Attribution-NonCommercial-NoDerivs 3.0 Unported</dc:rights>
    <dc:contributor>Tost, Heike</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Esslinger, Christine</dc:contributor>
    <dc:contributor>Schwarz, Adam J.</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/45881"/>
    <dc:creator>Tost, Heike</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/3.0/"/>
    <dc:creator>Grimm, Oliver</dc:creator>
    <dc:creator>Esslinger, Christine</dc:creator>
    <dc:creator>Morgen, Katrin</dc:creator>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Nein

Begutachtet

Ja