@article{Plichta2014-12Amygd-45881,
  year={2014},
  doi={10.1016/j.neuroimage.2014.09.059},
  title={Amygdala habituation : a reliable fMRI phenotype},
  volume={103},
  issn={1053-8119},
  journal={NeuroImage},
  pages={383--390},
  author={Plichta, Michael M. and Grimm, Oliver and Morgen, Katrin and Mier, Daniela and Sauer, Carina and Haddad, Leila and Tost, Heike and Esslinger, Christine and Kirsch, Peter and Schwarz, Adam J.}
}

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    <dc:creator>Mier, Daniela</dc:creator>
    <dc:contributor>Morgen, Katrin</dc:contributor>
    <dc:creator>Schwarz, Adam J.</dc:creator>
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    <dcterms:title>Amygdala habituation : a reliable fMRI phenotype</dcterms:title>
    <dc:creator>Kirsch, Peter</dc:creator>
    <dc:contributor>Sauer, Carina</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Grimm, Oliver</dc:contributor>
    <dc:contributor>Mier, Daniela</dc:contributor>
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    <dc:creator>Haddad, Leila</dc:creator>
    <dc:contributor>Haddad, Leila</dc:contributor>
    <dc:creator>Sauer, Carina</dc:creator>
    <dcterms:issued>2014-12</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-05-22T13:25:02Z</dc:date>
    <dc:creator>Plichta, Michael M.</dc:creator>
    <dc:contributor>Plichta, Michael M.</dc:contributor>
    <dcterms:abstract xml:lang="eng">Amygdala function is of high interest for cognitive, social and psychiatric neuroscience, emphasizing the need for reliable assessments in humans. Previous work has indicated unsatisfactorily low within-subject reliability of amygdala activation fMRI measures. Based on basic science evidence for strong habituation of amygdala response to repeated stimuli, we investigated whether a quantification of habituation provides additional information beyond the usual estimate of the overall mean activity. We assessed the within-subject reliability of amygdala habituation measures during a facial emotion matching paradigm in 25 healthy subjects. We extracted the amygdala signal decrement across the course of the fMRI run for the two test-retest measurement sessions and compared reliability estimates with previous findings based on mean response amplitude. Retest-reliability of the session-wise amygdala habituation was significantly higher than the evoked amygdala mean amplitude (intraclass correlation coefficients (ICC)=0.53 vs. 0.16). To test the task-specificity of this finding, we compared the retest-reliability of amygdala habituation across two different tasks. Significant amygdala response decrement was also seen in a cognitive task (n-back working memory) that did not per se activate the amygdala, but was totally unreliable in that context (ICC~0.0), arguing for task-specificity. Together the results show that emotion-dependent amygdala habituation is a robust and considerably more reliable index than the mean amplitude, and provides a robust potential endpoint for within-subject designs including pharmaco-fMRI studies.</dcterms:abstract>
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    <dc:contributor>Kirsch, Peter</dc:contributor>
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    <dc:contributor>Tost, Heike</dc:contributor>
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    <dc:contributor>Esslinger, Christine</dc:contributor>
    <dc:contributor>Schwarz, Adam J.</dc:contributor>
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    <dc:creator>Tost, Heike</dc:creator>
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    <dc:creator>Grimm, Oliver</dc:creator>
    <dc:creator>Esslinger, Christine</dc:creator>
    <dc:creator>Morgen, Katrin</dc:creator>
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