Synthesis of Enantiomerically Pure Diethyl 2-Pyrrolidinyl- and 5-0xo-2-pyrrolidinylphosphonates

Groth, Ulrich; Richter, Lutz; Schöllkopf, Ulrich

Synthesis of Enantiomerically Pure Diethyl 2-Pyrrolidinyl- and 5-0xo-2-pyrrolidinylphosphonates

Dateien

Synthesis_of_Enantiomerically_Pure_Diethyl_.pdfGröße: 829.66 KBDownloads: 283

Datum

1992

Autor:innen

Groth, Ulrich

Richter, Lutz

Schöllkopf, Ulrich

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Liebigs Annalen der Chemie. 1992, 1992(9), pp. 903-909. ISSN 0170-2041. eISSN 1099-0690. Available under: doi: 10.1002/jlac.1992199201150

Zusammenfassung

Enantiomerically pure 3- and 4-substituted phosphonic acid derivatives 5 of pyroglutamic acid were prepared by a Michael addition of the lithiated (+)-camphor derivative 2 to α,β-unsaturated esters and subsequent hydrolysis. The reduction of the lactams 5 with LiBH4/BF3·OEtz afforded substituted phosphonic acid analogues 7 of proline.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

Phosphoglutamic acids, Phosphoprolines, Michael additions, Lactams

Zitieren

ISO 690

GROTH, Ulrich, Lutz RICHTER, Ulrich SCHÖLLKOPF, 1992. Synthesis of Enantiomerically Pure Diethyl 2-Pyrrolidinyl- and 5-0xo-2-pyrrolidinylphosphonates. In: Liebigs Annalen der Chemie. 1992, 1992(9), pp. 903-909. ISSN 0170-2041. eISSN 1099-0690. Available under: doi: 10.1002/jlac.1992199201150

BibTex

@article{Groth1992Synth-9874,
  year={1992},
  doi={10.1002/jlac.1992199201150},
  title={Synthesis of Enantiomerically Pure Diethyl 2-Pyrrolidinyl- and 5-0xo-2-pyrrolidinylphosphonates},
  number={9},
  volume={1992},
  issn={0170-2041},
  journal={Liebigs Annalen der Chemie},
  pages={903--909},
  author={Groth, Ulrich and Richter, Lutz and Schöllkopf, Ulrich}
}

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