Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2024
Autor:innen
Inholz, Katharina
Anderl, Janet L.
Maurits, Elmer
Kirk, Christopher J.
Fan, R. Andrea
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Deutsche Forschungsgemeinschaft (DFG): GR 1517/27‐1
Projekt
Open Access-Veröffentlichung
Open Access Hybrid
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
European Journal of Immunology. Wiley, 2350613. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.202350613
Zusammenfassung

Immunoproteasomes are a special class of proteasomes, which can be induced with IFN‐γ in an inflammatory environment. In recent years, it became evident that certain immune cell types constitutively express high levels of immunoproteasomes. However, information regarding the basal expression of proteolytically active immunoproteasome subunits in different types of immune cells is still rare. Hence, we quantified standard proteasome subunits (β1c, β2c, β5c) and immunoproteasome subunits (LMP2, MECL‐1, LMP7) in the major murine (CD4+ T cells, CD8+ T cells, CD19+ B cells, CD11c+ dendritic cells, CD49d+ natural killer cells, Ly‐6G+ neutrophils) and human immune cell (CD4+ T cells, CD8+ T cells, CD19+ B cells, CD1c+ CD141+ myeloid dendritic cells, CD56+ natural killer cells, granulocytes) subsets. The different human immune cell types were isolated from peripheral blood and the murine immune cell subsets from spleen. We found that proteasomes of most immune cell subsets mainly consist of immunoproteasome subunits. Our data will serve as a reference and guideline for immunoproteasome expression and imply a special role of immunoproteasomes in immune cells.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Immunoproteasome, Immune cells, Proteasome, Expression, Lymphoid tissue
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690INHOLZ, Katharina, Janet L. ANDERL, Moritz KLAWITTER, Heike GOEBEL, Elmer MAURITS, Christopher J. KIRK, R. Andrea FAN, Michael BASLER, 2024. Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function. In: European Journal of Immunology. Wiley, 2350613. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.202350613
BibTex
@article{Inholz2024-03-08Prote-69894,
  year={2024},
  doi={10.1002/eji.202350613},
  title={Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function},
  issn={0014-2980},
  journal={European Journal of Immunology},
  author={Inholz, Katharina and Anderl, Janet L. and Klawitter, Moritz and Goebel, Heike and Maurits, Elmer and Kirk, Christopher J. and Fan, R. Andrea and Basler, Michael},
  note={Article Number: 2350613}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/69894">
    <dc:contributor>Fan, R. Andrea</dc:contributor>
    <dc:contributor>Goebel, Heike</dc:contributor>
    <dc:contributor>Inholz, Katharina</dc:contributor>
    <dc:contributor>Anderl, Janet L.</dc:contributor>
    <dc:contributor>Klawitter, Moritz</dc:contributor>
    <dc:creator>Klawitter, Moritz</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <dc:creator>Fan, R. Andrea</dc:creator>
    <dcterms:title>Proteasome composition in immune cells implies special immune‐cell‐specific immunoproteasome function</dcterms:title>
    <dc:language>ita</dc:language>
    <dc:contributor>Kirk, Christopher J.</dc:contributor>
    <dc:contributor>Maurits, Elmer</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2024-05-02T07:33:43Z</dcterms:available>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dc:creator>Basler, Michael</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Maurits, Elmer</dc:creator>
    <dc:creator>Inholz, Katharina</dc:creator>
    <dc:contributor>Basler, Michael</dc:contributor>
    <dc:creator>Anderl, Janet L.</dc:creator>
    <dcterms:abstract>Immunoproteasomes are a special class of proteasomes, which can be induced with IFN‐γ in an inflammatory environment. In recent years, it became evident that certain immune cell types constitutively express high levels of immunoproteasomes. However, information regarding the basal expression of proteolytically active immunoproteasome subunits in different types of immune cells is still rare. Hence, we quantified standard proteasome subunits (β1c, β2c, β5c) and immunoproteasome subunits (LMP2, MECL‐1, LMP7) in the major murine (CD4&lt;sup&gt;+&lt;/sup&gt; T cells, CD8&lt;sup&gt;+&lt;/sup&gt; T cells, CD19&lt;sup&gt;+&lt;/sup&gt; B cells, CD11c&lt;sup&gt;+&lt;/sup&gt; dendritic cells, CD49d&lt;sup&gt;+&lt;/sup&gt; natural killer cells, Ly‐6G&lt;sup&gt;+&lt;/sup&gt; neutrophils) and human immune cell (CD4&lt;sup&gt;+&lt;/sup&gt; T cells, CD8&lt;sup&gt;+&lt;/sup&gt; T cells, CD19&lt;sup&gt;+&lt;/sup&gt; B cells, CD1c&lt;sup&gt;+&lt;/sup&gt; CD141&lt;sup&gt;+&lt;/sup&gt; myeloid dendritic cells, CD56&lt;sup&gt;+&lt;/sup&gt; natural killer cells, granulocytes) subsets. The different human immune cell types were isolated from peripheral blood and the murine immune cell subsets from spleen. We found that proteasomes of most immune cell subsets mainly consist of immunoproteasome subunits. Our data will serve as a reference and guideline for immunoproteasome expression and imply a special role of immunoproteasomes in immune cells.</dcterms:abstract>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/69894"/>
    <dcterms:issued>2024-03-08</dcterms:issued>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Goebel, Heike</dc:creator>
    <dc:creator>Kirk, Christopher J.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2024-05-02T07:33:43Z</dc:date>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen