Histological and MRI brain atlas of the common shrew, Sorex araneus, with brain region-specific gene expression profiles

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2023
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Thomas, William R.
von Elverfeldt, Dominik
Reisert, Marco
Muturi, Marion
Dávalos, Liliana M.
Nieland, John D.
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Frontiers in Neuroanatomy. Frontiers. 2023, 17, 1168523. eISSN 1662-5129. Available under: doi: 10.3389/fnana.2023.1168523
Zusammenfassung

The common shrew, Sorex araneus, is a small mammal of growing interest in neuroscience research, as it exhibits dramatic and reversible seasonal changes in individual brain size and organization (a process known as Dehnel’s phenomenon). Despite decades of studies on this system, the mechanisms behind the structural changes during Dehnel’s phenomenon are not yet understood. To resolve these questions and foster research on this unique species, we present the first combined histological, magnetic resonance imaging (MRI), and transcriptomic atlas of the common shrew brain. Our integrated morphometric brain atlas provides easily obtainable and comparable anatomic structures, while transcriptomic mapping identified distinct expression profiles across most brain regions. These results suggest that high-resolution morphological and genetic research is pivotal for elucidating the mechanisms underlying Dehnel’s phenomenon while providing a communal resource for continued research on a model of natural mammalian regeneration. Morphometric and NCBI Sequencing Read Archive are available at https://doi.org/10.17617/3.HVW8ZN

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570 Biowissenschaften, Biologie
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Dehnel’s phenomenon, neocortex, hippocampus, hypothalamus, olfactory bulb, Soricidae
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ISO 690BALDONI, Cecilia, William R. THOMAS, Dominik VON ELVERFELDT, Marco REISERT, Javier LAZARO, Marion MUTURI, Liliana M. DÁVALOS, John D. NIELAND, Dina K. N. DECHMANN, 2023. Histological and MRI brain atlas of the common shrew, Sorex araneus, with brain region-specific gene expression profiles. In: Frontiers in Neuroanatomy. Frontiers. 2023, 17, 1168523. eISSN 1662-5129. Available under: doi: 10.3389/fnana.2023.1168523
BibTex
@article{Baldoni2023Histo-67203,
  year={2023},
  doi={10.3389/fnana.2023.1168523},
  title={Histological and MRI brain atlas of the common shrew, Sorex araneus, with brain region-specific gene expression profiles},
  volume={17},
  journal={Frontiers in Neuroanatomy},
  author={Baldoni, Cecilia and Thomas, William R. and von Elverfeldt, Dominik and Reisert, Marco and Lazaro, Javier and Muturi, Marion and Dávalos, Liliana M. and Nieland, John D. and Dechmann, Dina K. N.},
  note={Article Number: 1168523}
}
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