NMR.-study of nitrogen inversion and conformation of 1,5-dihydro-isoalloxazines ('Reduced Flavin')

Lade...
Vorschaubild
Dateien
NMR.pdf
NMR.pdfGröße: 959.93 KBDownloads: 670
Datum
1973
Autor:innen
Tauscher, Ludwig
Hemmerich, Peter
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Thc pyramidal inversion of the N(5)-centre of several reduced flavins was measured by NMR. The inversion barrier was found to be ~10 kcal/mol in acetone solutions and to be independent of the size of the N(5) substituent. An increase of the inversion barrier of ~5 kcal/mol was observed in the case where the N(5) substituent could only be in axial position, and an increase of ~3.5 kcal/mol was observed for an acyl-like N(5) substituent. In aqueous solution the inversion barrier increases by ~3 kcal/mol. The stereochemistry of reduced flavin and its potential relevance in flavin-dependent biological dehydrogenations is discussed.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690TAUSCHER, Ludwig, Sandro GHISLA, Peter HEMMERICH, 1973. NMR.-study of nitrogen inversion and conformation of 1,5-dihydro-isoalloxazines ('Reduced Flavin'). In: Helvetica Chimica Acta. 1973, 56(2), pp. 630-644. ISSN 0018-019X. eISSN 1522-2675. Available under: doi: 10.1002/hlca.19730560209
BibTex
@article{Tauscher1973NMRst-7448,
  year={1973},
  doi={10.1002/hlca.19730560209},
  title={NMR.-study of nitrogen inversion and conformation of 1,5-dihydro-isoalloxazines ('Reduced Flavin')},
  number={2},
  volume={56},
  issn={0018-019X},
  journal={Helvetica Chimica Acta},
  pages={630--644},
  author={Tauscher, Ludwig and Ghisla, Sandro and Hemmerich, Peter}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7448">
    <dc:contributor>Tauscher, Ludwig</dc:contributor>
    <dc:creator>Ghisla, Sandro</dc:creator>
    <dc:format>application/pdf</dc:format>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:34:30Z</dcterms:available>
    <dcterms:abstract xml:lang="deu">Thc pyramidal inversion of the N(5)-centre of several reduced flavins was measured by NMR. The inversion barrier was found to be ~10 kcal/mol in acetone solutions and to be independent of the size of the N(5) substituent. An increase of the inversion barrier of ~5 kcal/mol was observed in the case where the N(5) substituent could only be in axial position, and an increase of ~3.5 kcal/mol was observed for an acyl-like N(5) substituent. In aqueous solution the inversion barrier increases by ~3 kcal/mol. The stereochemistry of reduced flavin and its potential relevance in flavin-dependent biological dehydrogenations is discussed.</dcterms:abstract>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dc:contributor>Ghisla, Sandro</dc:contributor>
    <dc:contributor>Hemmerich, Peter</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7448/1/NMR.pdf"/>
    <dcterms:issued>1973</dcterms:issued>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7448"/>
    <dcterms:bibliographicCitation>First publ. in: Helvetica Chimica Acta 56 (1973), 2, pp. 630-644</dcterms:bibliographicCitation>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dc:creator>Hemmerich, Peter</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dcterms:title>NMR.-study of nitrogen inversion and conformation of 1,5-dihydro-isoalloxazines ('Reduced Flavin')</dcterms:title>
    <dc:creator>Tauscher, Ludwig</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:34:30Z</dc:date>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7448/1/NMR.pdf"/>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen