Fueling genome maintenance : On the versatile roles of NAD+ in preserving DNA integrity

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Journal of Biological Chemistry (JBC). Elsevier. 2022, 298(6), 102037. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1016/j.jbc.2022.102037
Zusammenfassung

Nicotinamide adenine dinucleotide (NAD+) is a versatile biomolecule acting as a master regulator and substrate in various cellular processes, including redox regulation, metabolism, and various signaling pathways. In this article, we concisely and critically review the role of NAD+ in mechanisms promoting genome maintenance. Numerous NAD+-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways regulating nucleic acid metabolism, such as gene expression and cell proliferation pathways. Of note, NAD+ serves as a substrate to ADP-ribosyltransferases (ARTs), sirtuins (SIRTs), and potentially also eukaryotic DNA ligases, all of which regulate various aspects of DNA integrity, damage repair, and gene expression. Finally, we critically analyze recent developments in the field as well as discuss challenges associated with therapeutic actions intended to raise NAD+ levels.

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570 Biowissenschaften, Biologie
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ISO 690RUSZKIEWICZ, Joanna A., Alexander BÜRKLE, Aswin MANGERICH, 2022. Fueling genome maintenance : On the versatile roles of NAD+ in preserving DNA integrity. In: Journal of Biological Chemistry (JBC). Elsevier. 2022, 298(6), 102037. ISSN 0021-9258. eISSN 1083-351X. Available under: doi: 10.1016/j.jbc.2022.102037
BibTex
@article{Ruszkiewicz2022-05-17Fueli-57636,
  year={2022},
  doi={10.1016/j.jbc.2022.102037},
  title={Fueling genome maintenance : On the versatile roles of NAD<sup>+</sup> in preserving DNA integrity},
  number={6},
  volume={298},
  issn={0021-9258},
  journal={Journal of Biological Chemistry (JBC)},
  author={Ruszkiewicz, Joanna A. and Bürkle, Alexander and Mangerich, Aswin},
  note={Article Number: 102037}
}
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    <dcterms:abstract xml:lang="eng">Nicotinamide adenine dinucleotide (NAD&lt;sup&gt;+&lt;/sup&gt;) is a versatile biomolecule acting as a master regulator and substrate in various cellular processes, including redox regulation, metabolism, and various signaling pathways. In this article, we concisely and critically review the role of NAD&lt;sup&gt;+&lt;/sup&gt; in mechanisms promoting genome maintenance. Numerous NAD&lt;sup&gt;+&lt;/sup&gt;-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways regulating nucleic acid metabolism, such as gene expression and cell proliferation pathways. Of note, NAD&lt;sup&gt;+&lt;/sup&gt; serves as a substrate to ADP-ribosyltransferases (ARTs), sirtuins (SIRTs), and potentially also eukaryotic DNA ligases, all of which regulate various aspects of DNA integrity, damage repair, and gene expression. Finally, we critically analyze recent developments in the field as well as discuss challenges associated with therapeutic actions intended to raise NAD&lt;sup&gt;+&lt;/sup&gt; levels.</dcterms:abstract>
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