@article{Marcon2016Hight-55590,
  year={2016},
  doi={10.7554/eLife.14022},
  title={High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals},
  volume={5},
  journal={eLife},
  author={Marcon, Luciano and Diego, Xavier and Sharpe, James and Müller, Patrick},
  note={Article Number: e14022}
}

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    <dc:contributor>Marcon, Luciano</dc:contributor>
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    <dcterms:title>High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals</dcterms:title>
    <dcterms:issued>2016</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-19T09:47:48Z</dc:date>
    <dc:creator>Diego, Xavier</dc:creator>
    <dcterms:abstract xml:lang="eng">The Turing reaction-diffusion model explains how identical cells can self-organize to form spatial patterns. It has been suggested that extracellular signaling molecules with different diffusion coefficients underlie this model, but the contribution of cell-autonomous signaling components is largely unknown. We developed an automated mathematical analysis to derive a catalog of realistic Turing networks. This analysis reveals that in the presence of cell-autonomous factors, networks can form a pattern with equally diffusing signals and even for any combination of diffusion coefficients. We provide a software (available at http://www.RDNets.com) to explore these networks and to constrain topologies with qualitative and quantitative experimental data. We use the software to examine the self-organizing networks that control embryonic axis specification and digit patterning. Finally, we demonstrate how existing synthetic circuits can be extended with additional feedbacks to form Turing reaction-diffusion systems. Our study offers a new theoretical framework to understand multicellular pattern formation and enables the wide-spread use of mathematical biology to engineer synthetic patterning systems.</dcterms:abstract>
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    <dc:creator>Müller, Patrick</dc:creator>
    <dc:creator>Marcon, Luciano</dc:creator>
    <dc:creator>Sharpe, James</dc:creator>
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    <dc:contributor>Sharpe, James</dc:contributor>
    <dc:contributor>Diego, Xavier</dc:contributor>
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    <dc:rights>Attribution 4.0 International</dc:rights>
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