The seahorse genome and the evolution of its specialized morphology

Seahorses have a specialized morphology that includes a toothless tubular mouth, a body covered with bony plates, a male brood pouch, and the absence of caudal and pelvic fins. Here we report the sequencing and de novo assembly of the genome of the tiger tail seahorse, Hippocampus comes. Comparative genomic analysis identifies higher protein and nucleotide evolutionary rates in H. comes compared with other teleost fish genomes. We identified an astacin metalloprotease gene family that has undergone expansion and is highly expressed in the male brood pouch. We also find that the H. comes genome lacks enamel matrix protein-coding proline/glutamine-rich secretory calcium-binding phosphoprotein genes, which might have led to the loss of mineralized teeth. tbx4, a regulator of hindlimb development, is also not found in H. comes genome. Knockout of tbx4 in zebrafish showed a 'pelvic fin-loss' phenotype similar to that of seahorses.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Genome, Evolutionary developmental biology

Zitieren

ISO 690

LIN, Qiang, Shaohua FAN, Yanhong ZHANG, Joost M. WOLTERING, Helen M. GUNTER, Ralf F. SCHNEIDER, Peiwen XIONG, Qiong SHI, Axel MEYER, Byrappa VENKATESH, 2016. The seahorse genome and the evolution of its specialized morphology. In: Nature. 2016, 540(7633), pp. 395-399. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/nature20595

BibTex

@article{Lin2016seaho-37086,
  year={2016},
  doi={10.1038/nature20595},
  title={The seahorse genome and the evolution of its specialized morphology},
  number={7633},
  volume={540},
  issn={0028-0836},
  journal={Nature},
  pages={395--399},
  author={Lin, Qiang and Fan, Shaohua and Zhang, Yanhong and Woltering, Joost M. and Gunter, Helen M. and Schneider, Ralf F. and Xiong, Peiwen and Shi, Qiong and Meyer, Axel and Venkatesh, Byrappa}
}

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Universitätsbibliographie

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