Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity : how to evaluate the risk of the S-EDCs?

Lade...
Vorschaubild
Dateien
Autrup_2-8mmkvlv4qfys8.pdf
Autrup_2-8mmkvlv4qfys8.pdfGröße: 602.13 KBDownloads: 101
Datum
2020
Autor:innen
Autrup, Herman
Barile, Frank A.
Berry, Sir Colin
Blaauboer, Bas J.
Boobis, Alan
Bolt, Herrmann
Borgert, Christopher J.
Dekant, Wolfgang
Greim, Helmut
et al.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690AUTRUP, Herman, Frank A. BARILE, Sir Colin BERRY, Bas J. BLAAUBOER, Alan BOOBIS, Herrmann BOLT, Christopher J. BORGERT, Wolfgang DEKANT, Daniel R. DIETRICH, Helmut GREIM, 2020. Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity : how to evaluate the risk of the S-EDCs?. In: Archives of Toxicology. Springer. 2020, 94(7), pp. 2549-2557. ISSN 0340-5761. eISSN 1432-0738. Available under: doi: 10.1007/s00204-020-02800-8
BibTex
@article{Autrup2020-07Human-50243,
  year={2020},
  doi={10.1007/s00204-020-02800-8},
  title={Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity : how to evaluate the risk of the S-EDCs?},
  number={7},
  volume={94},
  issn={0340-5761},
  journal={Archives of Toxicology},
  pages={2549--2557},
  author={Autrup, Herman and Barile, Frank A. and Berry, Sir Colin and Blaauboer, Bas J. and Boobis, Alan and Bolt, Herrmann and Borgert, Christopher J. and Dekant, Wolfgang and Dietrich, Daniel R. and Greim, Helmut}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/50243">
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/50243/1/Autrup_2-8mmkvlv4qfys8.pdf"/>
    <dcterms:abstract xml:lang="eng">Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower. Thus, to elicit observable effects, S-EDCs require considerably higher concentrations to attain sufficient receptor occupancy or to displace natural hormones and other endogenous ligands. Significant exposures to exogenous N-EDCs may result from ingestion of foods such as soy-based diets, green tea and sweet mustard. While their potencies are lower as compared to natural endogenous hormones, they usually are considerably more potent than S-EDCs. Effects of exogenous N-EDCs on the endocrine system were observed at high dietary intakes. A causal relation between their mechanism of action and these effects is established and biologically plausible. In contrast, the assumption that the much lower human exposures to S-EDCs may induce observable endocrine effects is not plausible. Hence, it is not surprising that epidemiological studies searching for an association between S-EDC exposure and health effects have failed. Regarding testing for potential endocrine effects, a scientifically justified screen should use in vitro tests to compare potencies of S-EDCs with those of reference N-EDCs. When the potency of the S-EDC is similar or smaller than that of the N-EDC, further testing in laboratory animals and regulatory consequences are not warranted.</dcterms:abstract>
    <dc:creator>Borgert, Christopher J.</dc:creator>
    <dc:contributor>Blaauboer, Bas J.</dc:contributor>
    <dc:contributor>Dekant, Wolfgang</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Berry, Sir Colin</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Barile, Frank A.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-07-14T13:37:28Z</dc:date>
    <dc:creator>Bolt, Herrmann</dc:creator>
    <dc:contributor>Borgert, Christopher J.</dc:contributor>
    <dc:creator>Boobis, Alan</dc:creator>
    <dc:creator>Barile, Frank A.</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:creator>Dietrich, Daniel R.</dc:creator>
    <dc:creator>Greim, Helmut</dc:creator>
    <dc:contributor>Autrup, Herman</dc:contributor>
    <dcterms:issued>2020-07</dcterms:issued>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/50243/1/Autrup_2-8mmkvlv4qfys8.pdf"/>
    <dcterms:title>Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity : how to evaluate the risk of the S-EDCs?</dcterms:title>
    <dc:contributor>Boobis, Alan</dc:contributor>
    <dc:contributor>Bolt, Herrmann</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Dietrich, Daniel R.</dc:contributor>
    <dc:creator>Dekant, Wolfgang</dc:creator>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-07-14T13:37:28Z</dcterms:available>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Berry, Sir Colin</dc:contributor>
    <dc:contributor>Greim, Helmut</dc:contributor>
    <dc:creator>Autrup, Herman</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/50243"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Blaauboer, Bas J.</dc:creator>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen