Polypharmacology of Approved Anticancer Drugs

Amelio, Ivano; Lisitsa, Andrey; Knight, Richard A.; Melino, Gerry; Antonov, Alexey V.

Polypharmacology of Approved Anticancer Drugs

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2017

Autor:innen

Amelio, Ivano

Lisitsa, Andrey

Knight, Richard A.

Melino, Gerry

Antonov, Alexey V.

DOI (zitierfähiger Link)

https://doi.org/10.2174/1389450117666160301095233

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Current Drug Targets. Bentham Science. 2017, 18(5), pp. 534-543. ISSN 1389-4501. eISSN 1873-5592. Available under: doi: 10.2174/1389450117666160301095233

Zusammenfassung

The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Polypharmacology, tyrosine kinase inhibitors, histone deacetylase inhibitors, DNA topoisomerase inhibitors, tamoxifen, drug targets, rational design of multitarget drugs

Zitieren

ISO 690

AMELIO, Ivano, Andrey LISITSA, Richard A. KNIGHT, Gerry MELINO, Alexey V. ANTONOV, 2017. Polypharmacology of Approved Anticancer Drugs. In: Current Drug Targets. Bentham Science. 2017, 18(5), pp. 534-543. ISSN 1389-4501. eISSN 1873-5592. Available under: doi: 10.2174/1389450117666160301095233

BibTex

@article{Amelio2017Polyp-56667,
  year={2017},
  doi={10.2174/1389450117666160301095233},
  title={Polypharmacology of Approved Anticancer Drugs},
  number={5},
  volume={18},
  issn={1389-4501},
  journal={Current Drug Targets},
  pages={534--543},
  author={Amelio, Ivano and Lisitsa, Andrey and Knight, Richard A. and Melino, Gerry and Antonov, Alexey V.}
}

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