Publikation:

Polypharmacology of Approved Anticancer Drugs

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2017

Autor:innen

Lisitsa, Andrey
Knight, Richard A.
Melino, Gerry
Antonov, Alexey V.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.2174/1389450117666160301095233
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Current Drug Targets. Bentham Science. 2017, 18(5), pp. 534-543. ISSN 1389-4501. eISSN 1873-5592. Available under: doi: 10.2174/1389450117666160301095233

Zusammenfassung

The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Polypharmacology, tyrosine kinase inhibitors, histone deacetylase inhibitors, DNA topoisomerase inhibitors, tamoxifen, drug targets, rational design of multitarget drugs

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690AMELIO, Ivano, Andrey LISITSA, Richard A. KNIGHT, Gerry MELINO, Alexey V. ANTONOV, 2017. Polypharmacology of Approved Anticancer Drugs. In: Current Drug Targets. Bentham Science. 2017, 18(5), pp. 534-543. ISSN 1389-4501. eISSN 1873-5592. Available under: doi: 10.2174/1389450117666160301095233
BibTex
@article{Amelio2017Polyp-56667,
  year={2017},
  doi={10.2174/1389450117666160301095233},
  title={Polypharmacology of Approved Anticancer Drugs},
  number={5},
  volume={18},
  issn={1389-4501},
  journal={Current Drug Targets},
  pages={534--543},
  author={Amelio, Ivano and Lisitsa, Andrey and Knight, Richard A. and Melino, Gerry and Antonov, Alexey V.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/56667">
    <dc:creator>Amelio, Ivano</dc:creator>
    <dc:creator>Melino, Gerry</dc:creator>
    <dcterms:title>Polypharmacology of Approved Anticancer Drugs</dcterms:title>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms.</dcterms:abstract>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:issued>2017</dcterms:issued>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-23T14:42:45Z</dc:date>
    <dc:contributor>Knight, Richard A.</dc:contributor>
    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dc:contributor>Lisitsa, Andrey</dc:contributor>
    <dc:contributor>Antonov, Alexey V.</dc:contributor>
    <dc:creator>Knight, Richard A.</dc:creator>
    <dc:creator>Antonov, Alexey V.</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56667"/>
    <dc:creator>Lisitsa, Andrey</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Melino, Gerry</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-23T14:42:45Z</dcterms:available>
    <dc:rights>terms-of-use</dc:rights>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen