Publikation:

The multiple effects of amino acids on the early stages of calcium carbonate crystallization

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2012

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Zeitschrift für Kristallographie - Crystalline Materials. 2012, 227(11), pp. 744-757. ISSN 2194-4946. Available under: doi: 10.1524/zkri.2012.1569

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Proteins have found their way into many of Nature’s structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO3 mineralization – either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO3 crystallization. These same amino acids have been independently implicated as constituents in liquid-like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.

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540 Chemie

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ISO 690PICKER, Andreas, Matthias KELLERMEIER, Jong SETO, Denis GEBAUER, Helmut CÖLFEN, 2012. The multiple effects of amino acids on the early stages of calcium carbonate crystallization. In: Zeitschrift für Kristallographie - Crystalline Materials. 2012, 227(11), pp. 744-757. ISSN 2194-4946. Available under: doi: 10.1524/zkri.2012.1569
BibTex
@article{Picker2012multi-20955,
  year={2012},
  doi={10.1524/zkri.2012.1569},
  title={The multiple effects of amino acids on the early stages of calcium carbonate crystallization},
  number={11},
  volume={227},
  issn={2194-4946},
  journal={Zeitschrift für Kristallographie - Crystalline Materials},
  pages={744--757},
  author={Picker, Andreas and Kellermeier, Matthias and Seto, Jong and Gebauer, Denis and Cölfen, Helmut}
}
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