Membrane-mediated Protein-protein Interaction : A Monte Carlo Study

Neder, Jörg; West, Beate; Nielaba, Peter; Schmid, Friederike

Membrane-mediated Protein-protein Interaction : A Monte Carlo Study

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2011

Autor:innen

Neder, Jörg

West, Beate

Nielaba, Peter

Schmid, Friederike

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Current Nanoscience. 2011, 7(5), pp. 656-666. Available under: doi: 10.2174/157341311797483655

Zusammenfassung

We investigate membrane-mediated interactions between transmembrane proteins using coarse-grained models. We compare the effective potential of mean force (PMF) between two proteins, which are always aligned parallel to the z-axis of the simulation box, with those PMFs obtained for proteins with fluctuating orientations. The PMFs are dominated by an oscillatory packing-driven contribution and a smooth attractive hydrophobic mismatch contribution, which vanishes if the hydrophobic length of the protein matches the thickness of the membrane. If protein orientations are allowed to fluctuate, the oscillations are greatly reduced compared to proteins with fixed orientation. Furthermore, the hydrophobic mismatch interaction has a smaller range. Finally, we compare the two-dimensional thickness profiles around two proteins with the predictions from the elastic theory of two coupled monolayers, and find them to be in
very good agreement.

Fachgebiet (DDC)

530 Physik

Schlagwörter

biomembranes, elasticity, lipid bilayers, Monte Carlo methods, coarse-graining, potential of mean force, hydrophobic mismatch, lipid layering

Zitieren

ISO 690

NEDER, Jörg, Beate WEST, Peter NIELABA, Friederike SCHMID, 2011. Membrane-mediated Protein-protein Interaction : A Monte Carlo Study. In: Current Nanoscience. 2011, 7(5), pp. 656-666. Available under: doi: 10.2174/157341311797483655

BibTex

@article{Neder2011Membr-16674,
  year={2011},
  doi={10.2174/157341311797483655},
  title={Membrane-mediated Protein-protein Interaction : A Monte Carlo Study},
  number={5},
  volume={7},
  journal={Current Nanoscience},
  pages={656--666},
  author={Neder, Jörg and West, Beate and Nielaba, Peter and Schmid, Friederike}
}

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Universitätsbibliographie

Ja