Neural correlates of water reward in thirsty Drosophila

Lin, Suewei; Owald, David; Chandra, Vikram; Talbot, Clifford; Huetteroth, Wolf; Waddell, Scott

Neural correlates of water reward in thirsty Drosophila

Files

Lin_0-257620.pdf(224.51 KB)

Date

2014

Authors

Lin, Suewei

Owald, David

Chandra, Vikram

Talbot, Clifford

Huetteroth, Wolf

Waddell, Scott

Publication type

Journal article

Published in

Nature Neuroscience ; 17 (2014), 11. - pp. 1536-1542. - ISSN 1097-6256. - eISSN 1546-1726

Abstract

Drinking water is innately rewarding to thirsty animals. In addition, the consumed value can be assigned to behavioral actions and predictive sensory cues by associative learning. Here we show that thirst converts water avoidance into water-seeking in naive Drosophila melanogaster. Thirst also permitted flies to learn olfactory cues paired with water reward. Water learning required water taste and <40 water-responsive dopaminergic neurons that innervate a restricted zone of the mushroom body γ lobe. These water learning neurons are different from those that are critical for conveying the reinforcing effects of sugar. Naive water-seeking behavior in thirsty flies did not require water taste but relied on another subset of water-responsive dopaminergic neurons that target the mushroom body β' lobe. Furthermore, these naive water-approach neurons were not required for learned water-seeking. Our results therefore demonstrate that naive water-seeking, learned water-seeking and water learning use separable neural circuitry in the brain of thirsty flies.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

LIN, Suewei, David OWALD, Vikram CHANDRA, Clifford TALBOT, Wolf HUETTEROTH, Scott WADDELL, 2014. Neural correlates of water reward in thirsty Drosophila. In: Nature Neuroscience. 17(11), pp. 1536-1542. ISSN 1097-6256. eISSN 1546-1726. Available under: doi: 10.1038/nn.3827

BibTex

@article{Lin2014Neura-29140,
  year={2014},
  doi={10.1038/nn.3827},
  title={Neural correlates of water reward in thirsty Drosophila},
  number={11},
  volume={17},
  issn={1097-6256},
  journal={Nature Neuroscience},
  pages={1536--1542},
  author={Lin, Suewei and Owald, David and Chandra, Vikram and Talbot, Clifford and Huetteroth, Wolf and Waddell, Scott}
}

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