Poly(ADP-Ribosyl)ation, PARP, and Aging

Beneke, Sascha; Bürkle, Alexander

Poly(ADP-Ribosyl)ation, PARP, and Aging

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Datum

2004

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Science of Aging Knowledge Environment (SAGE KE). American Association for the Advancement of Science. 2004(49), re9. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9

Zusammenfassung

Poly(ADP-ribose) polymerases (PARPs) catalyze the poly(ADP-ribosyl)ation of proteins. This posttranslational modification, as generated by the DNA damage-activated enzymes PARP-1 and -2, has long been known to be involved in DNA repair. Correlative data have suggested an association between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity, and this link has recently been strengthened by the discovery of interactions between PARP-1 and the Werner syndrome protein. Emerging additional members of the PARP family display different cellular localizations and are involved in diverse processes such as the regulation of telomere or centrosome function, thereby providing further, independent links between poly(ADP-ribosyl)ation and the aging process.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

centrosome, DNA repair, genomic stability, PARP, poly(ADP-ribosyl)ation, telomere

Zitieren

ISO 690

BENEKE, Sascha, Alexander BÜRKLE, 2004. Poly(ADP-Ribosyl)ation, PARP, and Aging. In: Science of Aging Knowledge Environment (SAGE KE). American Association for the Advancement of Science. 2004(49), re9. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9

BibTex

@article{Beneke2004-12-08PolyA-53283,
  year={2004},
  doi={10.1126/sageke.2004.49.re9},
  title={Poly(ADP-Ribosyl)ation, PARP, and Aging},
  number={49},
  journal={Science of Aging Knowledge Environment (SAGE KE)},
  author={Beneke, Sascha and Bürkle, Alexander},
  note={Article Number: re9}
}

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