Poly(ADP-Ribosyl)ation, PARP, and Aging

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2004
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Science of Aging Knowledge Environment (SAGE KE). American Association for the Advancement of Science. 2004(49), re9. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9
Zusammenfassung

Poly(ADP-ribose) polymerases (PARPs) catalyze the poly(ADP-ribosyl)ation of proteins. This posttranslational modification, as generated by the DNA damage-activated enzymes PARP-1 and -2, has long been known to be involved in DNA repair. Correlative data have suggested an association between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity, and this link has recently been strengthened by the discovery of interactions between PARP-1 and the Werner syndrome protein. Emerging additional members of the PARP family display different cellular localizations and are involved in diverse processes such as the regulation of telomere or centrosome function, thereby providing further, independent links between poly(ADP-ribosyl)ation and the aging process.

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570 Biowissenschaften, Biologie
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centrosome, DNA repair, genomic stability, PARP, poly(ADP-ribosyl)ation, telomere
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ISO 690BENEKE, Sascha, Alexander BÜRKLE, 2004. Poly(ADP-Ribosyl)ation, PARP, and Aging. In: Science of Aging Knowledge Environment (SAGE KE). American Association for the Advancement of Science. 2004(49), re9. eISSN 1539-6150. Available under: doi: 10.1126/sageke.2004.49.re9
BibTex
@article{Beneke2004-12-08PolyA-53283,
  year={2004},
  doi={10.1126/sageke.2004.49.re9},
  title={Poly(ADP-Ribosyl)ation, PARP, and Aging},
  number={49},
  journal={Science of Aging Knowledge Environment (SAGE KE)},
  author={Beneke, Sascha and Bürkle, Alexander},
  note={Article Number: re9}
}
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