Publikation: Synthesis of the repeating unit of the lipoteichoic acid of streptococcus pneumoniae
Lade...
Dateien
Datum
2012
Autor:innen
Pedersen, Christian Marcus
Figueroa-Perez, Ignacio
Ulmer, Artur J.
Zähringer, Ulrich
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Tetrahedron. 2012, 68(4), pp. 1052-1061. ISSN 0040-4020. Available under: doi: 10.1016/j.tet.2011.11.088
Zusammenfassung
The lipoteichoic acid repeating unit of Streptococcus pneumoniae is a complex pseudopentasaccharide (3).
It consists of one ribitol-phosphate, one 2-acetamino-4-amino-2,4,6-trideoxy-galactose, one glucose and two galactosamine residues each differently linked, but both carrying one phosphocholine substituent, at position 6. Suitable building blocks (6e10) for efficient and diastereocontrolled ligations were designed, thus providing, after complete deprotection, the target molecule in high purity. Biological tests revealed that repeating unit 3, lacking the lipid moiety, did not stimulate a pro-inflammatory response in human monocytes (hMNCs).
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
Gram-positive bacteria, Glycosylation, Cytokines, Lipoteichoic acid, Carbohydrates
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
PEDERSEN, Christian Marcus, Ignacio FIGUEROA-PEREZ, Artur J. ULMER, Ulrich ZÄHRINGER, Richard R. SCHMIDT, 2012. Synthesis of the repeating unit of the lipoteichoic acid of streptococcus pneumoniae. In: Tetrahedron. 2012, 68(4), pp. 1052-1061. ISSN 0040-4020. Available under: doi: 10.1016/j.tet.2011.11.088BibTex
@article{Pedersen2012Synth-18127, year={2012}, doi={10.1016/j.tet.2011.11.088}, title={Synthesis of the repeating unit of the lipoteichoic acid of streptococcus pneumoniae}, number={4}, volume={68}, issn={0040-4020}, journal={Tetrahedron}, pages={1052--1061}, author={Pedersen, Christian Marcus and Figueroa-Perez, Ignacio and Ulmer, Artur J. and Zähringer, Ulrich and Schmidt, Richard R.} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/18127"> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/18127/2/Schmidt%20etal.pdf"/> <dc:contributor>Pedersen, Christian Marcus</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-14T12:04:52Z</dcterms:available> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Figueroa-Perez, Ignacio</dc:contributor> <dcterms:issued>2012</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/18127"/> <dcterms:title>Synthesis of the repeating unit of the lipoteichoic acid of streptococcus pneumoniae</dcterms:title> <dc:creator>Figueroa-Perez, Ignacio</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/18127/2/Schmidt%20etal.pdf"/> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Zähringer, Ulrich</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-02-14T12:04:52Z</dc:date> <dc:contributor>Schmidt, Richard R.</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Schmidt, Richard R.</dc:creator> <dc:creator>Zähringer, Ulrich</dc:creator> <dc:creator>Ulmer, Artur J.</dc:creator> <dc:contributor>Ulmer, Artur J.</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Tetrahedron ; 68 (2011), 4. - pp. 1052-1061</dcterms:bibliographicCitation> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dc:creator>Pedersen, Christian Marcus</dc:creator> <dcterms:abstract xml:lang="eng">The lipoteichoic acid repeating unit of Streptococcus pneumoniae is a complex pseudopentasaccharide (3).<br />It consists of one ribitol-phosphate, one 2-acetamino-4-amino-2,4,6-trideoxy-galactose, one glucose and two galactosamine residues each differently linked, but both carrying one phosphocholine substituent, at position 6. Suitable building blocks (6e10) for efficient and diastereocontrolled ligations were designed, thus providing, after complete deprotection, the target molecule in high purity. Biological tests revealed that repeating unit 3, lacking the lipid moiety, did not stimulate a pro-inflammatory response in human monocytes (hMNCs).</dcterms:abstract> </rdf:Description> </rdf:RDF>