Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study

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Abstract Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE (“European study to establish bioMARKers of human AGEing“) participants ( N  = 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 – 0.310], p  = 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 – 4.372], p  = 0.007; and adjusted odds ratio = 1.414 [1.025 – 1.951], p  = 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.

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570 Biowissenschaften, Biologie
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GDF 15, Cognitive frailty, Depression, Aging, Biomarker
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ISO 690KOCHLIK, Bastian, Catrin HERPICH, Maria MORENO-VILLANUEVA, Susanne KLAUS, Ursula MÜLLER-WERDAN, Birgit WEINBERGER, Simone FIEGL, Olivier TOUSSAINT, Florence DEBACQ-CHAINIAUX, Alexander BÜRKLE, 2023. Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study. In: GeroScience. Springer. eISSN 2509-2723. Available under: doi: 10.1007/s11357-023-00902-6
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@article{Kochlik2023-09-16Assoc-67866,
  year={2023},
  doi={10.1007/s11357-023-00902-6},
  title={Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study},
  journal={GeroScience},
  author={Kochlik, Bastian and Herpich, Catrin and Moreno-Villanueva, Maria and Klaus, Susanne and Müller-Werdan, Ursula and Weinberger, Birgit and Fiegl, Simone and Toussaint, Olivier and Debacq-Chainiaux, Florence and Bürkle, Alexander}
}
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