The immunoproteasome in antigen processing and other immunological functions

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Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.

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ISO 690BASLER, Michael, Christopher J. KIRK, Marcus GRÖTTRUP, 2013. The immunoproteasome in antigen processing and other immunological functions. In: Current Opinion in Immunology. 2013, 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2012.11.004
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@article{Basler2013-02immun-21986,
  year={2013},
  doi={10.1016/j.coi.2012.11.004},
  title={The immunoproteasome in antigen processing and other immunological functions},
  number={1},
  volume={25},
  issn={0952-7915},
  journal={Current Opinion in Immunology},
  pages={74--80},
  author={Basler, Michael and Kirk, Christopher J. and Gröttrup, Marcus}
}
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