The immunoproteasome in antigen processing and other immunological functions

Basler, Michael; Kirk, Christopher J.; Gröttrup, Marcus

The immunoproteasome in antigen processing and other immunological functions

Dateien

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Datum

2013

Autor:innen

Basler, Michael

Kirk, Christopher J.

Gröttrup, Marcus

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Current Opinion in Immunology. 2013, 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2012.11.004

Zusammenfassung

Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

BASLER, Michael, Christopher J. KIRK, Marcus GRÖTTRUP, 2013. The immunoproteasome in antigen processing and other immunological functions. In: Current Opinion in Immunology. 2013, 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2012.11.004

BibTex

@article{Basler2013-02immun-21986,
  year={2013},
  doi={10.1016/j.coi.2012.11.004},
  title={The immunoproteasome in antigen processing and other immunological functions},
  number={1},
  volume={25},
  issn={0952-7915},
  journal={Current Opinion in Immunology},
  pages={74--80},
  author={Basler, Michael and Kirk, Christopher J. and Gröttrup, Marcus}
}

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