The immunoproteasome in antigen processing and other immunological functions
The immunoproteasome in antigen processing and other immunological functions
Loading...
Date
2013
Authors
Editors
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Title in another language
Publication type
Journal article
Publication status
Published in
Current Opinion in Immunology ; 25 (2013), 1. - pp. 74-80. - ISSN 0952-7915. - eISSN 1879-0372
Abstract
Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.
Summary in another language
Subject (DDC)
570 Biosciences, Biology
Keywords
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690
BASLER, Michael, Christopher J. KIRK, Marcus GRÖTTRUP, 2013. The immunoproteasome in antigen processing and other immunological functions. In: Current Opinion in Immunology. 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2012.11.004BibTex
@article{Basler2013-02immun-21986, year={2013}, doi={10.1016/j.coi.2012.11.004}, title={The immunoproteasome in antigen processing and other immunological functions}, number={1}, volume={25}, issn={0952-7915}, journal={Current Opinion in Immunology}, pages={74--80}, author={Basler, Michael and Kirk, Christopher J. and Gröttrup, Marcus} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/21986"> <dcterms:title>The immunoproteasome in antigen processing and other immunological functions</dcterms:title> <dc:contributor>Basler, Michael</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21986/2/Basler_219861.pdf"/> <dc:creator>Kirk, Christopher J.</dc:creator> <dcterms:bibliographicCitation>Current Opinion in Immunology ; 25 (2013), 1. - S. 74-80</dcterms:bibliographicCitation> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-12T10:26:50Z</dc:date> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-12T10:26:50Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/21986"/> <dc:contributor>Kirk, Christopher J.</dc:contributor> <dc:creator>Basler, Michael</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21986/2/Basler_219861.pdf"/> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:issued>2013-02</dcterms:issued> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.</dcterms:abstract> <dc:language>eng</dc:language> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes