Publikation: The immunoproteasome in antigen processing and other immunological functions
Lade...
Dateien
Datum
2013
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Current Opinion in Immunology. 2013, 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2012.11.004
Zusammenfassung
Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
BASLER, Michael, Christopher J. KIRK, Marcus GRÖTTRUP, 2013. The immunoproteasome in antigen processing and other immunological functions. In: Current Opinion in Immunology. 2013, 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372. Available under: doi: 10.1016/j.coi.2012.11.004BibTex
@article{Basler2013-02immun-21986,
year={2013},
doi={10.1016/j.coi.2012.11.004},
title={The immunoproteasome in antigen processing and other immunological functions},
number={1},
volume={25},
issn={0952-7915},
journal={Current Opinion in Immunology},
pages={74--80},
author={Basler, Michael and Kirk, Christopher J. and Gröttrup, Marcus}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/21986">
<dcterms:title>The immunoproteasome in antigen processing and other immunological functions</dcterms:title>
<dc:contributor>Basler, Michael</dc:contributor>
<dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21986/2/Basler_219861.pdf"/>
<dc:creator>Kirk, Christopher J.</dc:creator>
<dcterms:bibliographicCitation>Current Opinion in Immunology ; 25 (2013), 1. - S. 74-80</dcterms:bibliographicCitation>
<dc:contributor>Gröttrup, Marcus</dc:contributor>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-12T10:26:50Z</dc:date>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-12T10:26:50Z</dcterms:available>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/21986"/>
<dc:contributor>Kirk, Christopher J.</dc:contributor>
<dc:creator>Basler, Michael</dc:creator>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21986/2/Basler_219861.pdf"/>
<dc:creator>Gröttrup, Marcus</dc:creator>
<dcterms:issued>2013-02</dcterms:issued>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dcterms:abstract xml:lang="eng">Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.</dcterms:abstract>
<dc:language>eng</dc:language>
<dc:rights>terms-of-use</dc:rights>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
