Publikation:

Adiposity Is Associated with Blunted Cardiovascular, Neuroendocrine and Cognitive Responses to Acute Mental Stress

Lade...
Vorschaubild

Dateien

Jones_0-402077.pdf
Jones_0-402077.pdfGröße: 372.55 KBDownloads: 237

Datum

2012

Autor:innen

Jones, Alexander
McMillan, Merlin R.
Jones, Russell W.
Kowalik, Grzegorz T.
Steeden, Jennifer A.
Deanfield, John E.
Taylor, Andrew M.
Muthurangu, Vivek

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

PLoS ONE. 2012, 7(6), e39143. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0039143

Zusammenfassung

Obesity and mental stress are potent risk factors for cardiovascular disease but their relationship with each other is unclear. Resilience to stress may differ according to adiposity. Early studies that addressed this are difficult to interpret due to conflicting findings and limited methods. Recent advances in assessment of cardiovascular stress responses and of fat distribution allow accurate assessment of associations between adiposity and stress responsiveness. We measured responses to the Montreal Imaging Stress Task in healthy men (N = 43) and women (N = 45) with a wide range of BMIs. Heart rate (HR) and blood pressure (BP) measures were used with novel magnetic resonance measures of stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR) and arterial compliance to assess cardiovascular responses. Salivary cortisol and the number and speed of answers to mathematics problems in the task were used to assess neuroendocrine and cognitive responses, respectively. Visceral and subcutaneous fat was measured using T(2) (*)-IDEAL. Greater BMI was associated with generalised blunting of cardiovascular (HR:β = -0.50 bpm x unit(-1), P = 0.009; SV:β = -0.33 mL x unit(-1), P = 0.01; CO:β = -61 mL x min(-1) x unit(-1), P = 0.002; systolic BP:β = -0.41 mmHg x unit(-1), P = 0.01; TPR:β = 0.11 WU x unit(-1), P = 0.02), cognitive (correct answers: r = -0.28, P = 0.01; time to answer: r = 0.26, P = 0.02) and endocrine responses (cortisol: r = -0.25, P = 0.04) to stress. These associations were largely determined by visceral adiposity except for those related to cognitive performance, which were determined by both visceral and subcutaneous adiposity. Our findings suggest that adiposity is associated with centrally reduced stress responsiveness. Although this may mitigate some long-term health risks of stress responsiveness, reduced performance under stress may be a more immediate negative consequence.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690JONES, Alexander, Merlin R. MCMILLAN, Russell W. JONES, Grzegorz T. KOWALIK, Jennifer A. STEEDEN, John E. DEANFIELD, Jens C. PRUESSNER, Andrew M. TAYLOR, Vivek MUTHURANGU, 2012. Adiposity Is Associated with Blunted Cardiovascular, Neuroendocrine and Cognitive Responses to Acute Mental Stress. In: PLoS ONE. 2012, 7(6), e39143. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0039143
BibTex
@article{Jones2012-06-20Adipo-38498,
  year={2012},
  doi={10.1371/journal.pone.0039143},
  title={Adiposity Is Associated with Blunted Cardiovascular, Neuroendocrine and Cognitive Responses to Acute Mental Stress},
  number={6},
  volume={7},
  journal={PLoS ONE},
  author={Jones, Alexander and McMillan, Merlin R. and Jones, Russell W. and Kowalik, Grzegorz T. and Steeden, Jennifer A. and Deanfield, John E. and Pruessner, Jens C. and Taylor, Andrew M. and Muthurangu, Vivek},
  note={Article Number: e39143}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38498">
    <dc:contributor>Deanfield, John E.</dc:contributor>
    <dc:creator>Jones, Russell W.</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">Obesity and mental stress are potent risk factors for cardiovascular disease but their relationship with each other is unclear. Resilience to stress may differ according to adiposity. Early studies that addressed this are difficult to interpret due to conflicting findings and limited methods. Recent advances in assessment of cardiovascular stress responses and of fat distribution allow accurate assessment of associations between adiposity and stress responsiveness. We measured responses to the Montreal Imaging Stress Task in healthy men (N = 43) and women (N = 45) with a wide range of BMIs. Heart rate (HR) and blood pressure (BP) measures were used with novel magnetic resonance measures of stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR) and arterial compliance to assess cardiovascular responses. Salivary cortisol and the number and speed of answers to mathematics problems in the task were used to assess neuroendocrine and cognitive responses, respectively. Visceral and subcutaneous fat was measured using T(2) (*)-IDEAL. Greater BMI was associated with generalised blunting of cardiovascular (HR:β = -0.50 bpm x unit(-1), P = 0.009; SV:β = -0.33 mL x unit(-1), P = 0.01; CO:β = -61 mL x min(-1) x unit(-1), P = 0.002; systolic BP:β = -0.41 mmHg x unit(-1), P = 0.01; TPR:β = 0.11 WU x unit(-1), P = 0.02), cognitive (correct answers: r = -0.28, P = 0.01; time to answer: r = 0.26, P = 0.02) and endocrine responses (cortisol: r = -0.25, P = 0.04) to stress. These associations were largely determined by visceral adiposity except for those related to cognitive performance, which were determined by both visceral and subcutaneous adiposity. Our findings suggest that adiposity is associated with centrally reduced stress responsiveness. Although this may mitigate some long-term health risks of stress responsiveness, reduced performance under stress may be a more immediate negative consequence.</dcterms:abstract>
    <dc:contributor>Steeden, Jennifer A.</dc:contributor>
    <dc:contributor>McMillan, Merlin R.</dc:contributor>
    <dcterms:issued>2012-06-20</dcterms:issued>
    <dc:contributor>Jones, Alexander</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Deanfield, John E.</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38498/3/Jones_0-402077.pdf"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38498/3/Jones_0-402077.pdf"/>
    <dc:contributor>Taylor, Andrew M.</dc:contributor>
    <dcterms:title>Adiposity Is Associated with Blunted Cardiovascular, Neuroendocrine and Cognitive Responses to Acute Mental Stress</dcterms:title>
    <dc:creator>Steeden, Jennifer A.</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Taylor, Andrew M.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-18T07:55:34Z</dc:date>
    <dc:creator>Muthurangu, Vivek</dc:creator>
    <dc:contributor>Jones, Russell W.</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>McMillan, Merlin R.</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38498"/>
    <dc:contributor>Kowalik, Grzegorz T.</dc:contributor>
    <dc:creator>Kowalik, Grzegorz T.</dc:creator>
    <dc:creator>Jones, Alexander</dc:creator>
    <dc:contributor>Muthurangu, Vivek</dc:contributor>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-18T07:55:34Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen