Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish

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2017
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Symonová, Radka
Majtánová, Zuzana
Arias-Rodriguez, Lenin
Mořkovský, Libor
Kořínková, Tereza
Cavin, Lionel
Pokorná, Martina Johnson
Doležálková, Marie
Flajšhans, Martin
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Journal of experimental zoology part B : molecular and developmental evolution. 2017, 328(7), pp. 607-619. ISSN 1552-5007. eISSN 1552-5015. Available under: doi: 10.1002/jez.b.22719
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Genomic GC content can vary locally, and GC-rich regions are usually associated with increased DNA thermostability in thermophilic prokaryotes and warm-blooded eukaryotes. Among vertebrates, fish and amphibians appeared to possess a distinctly less heterogeneous AT/GC organization in their genomes, whereas cytogenetically detectable GC heterogeneity has so far only been documented in mammals and birds. The subject of our study is the gar, an ancient "living fossil" of a basal ray-finned fish lineage, known from the Cretaceous period. We carried out cytogenomic analysis in two gar genera (Atractosteus and Lepisosteus) uncovering a GC chromosomal pattern uncharacteristic for fish. Bioinformatic analysis of the spotted gar (Lepisosteus oculatus) confirmed a GC compartmentalization on GC profiles of linkage groups. This indicates a rather mammalian mode of compositional organization on gar chromosomes. Gars are thus the only analyzed extant ray-finned fishes with a GC compartmentalized genome. Since gars are cold-blooded anamniotes, our results contradict the generally accepted hypothesis that the phylogenomic onset of GC compartmentalization occurred near the origin of amniotes. Ecophysiological findings of other authors indicate a metabolic similarity of gars with mammals. We hypothesize that gars might have undergone convergent evolution with the tetrapod lineages leading to mammals on both metabolic and genomic levels. Their metabolic adaptations might have left footprints in their compositional genome evolution, as proposed by the metabolic rate hypothesis. The genome organization described here in gars sheds new light on the compositional genome evolution in vertebrates generally and contributes to better understanding of the complexities of the mechanisms involved in this process.

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ISO 690SYMONOVÁ, Radka, Zuzana MAJTÁNOVÁ, Lenin ARIAS-RODRIGUEZ, Libor MOŘKOVSKÝ, Tereza KOŘÍNKOVÁ, Lionel CAVIN, Martina Johnson POKORNÁ, Marie DOLEŽÁLKOVÁ, Martin FLAJŠHANS, Axel MEYER, 2017. Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish. In: Journal of experimental zoology part B : molecular and developmental evolution. 2017, 328(7), pp. 607-619. ISSN 1552-5007. eISSN 1552-5015. Available under: doi: 10.1002/jez.b.22719
BibTex
@article{Symonova2017-11Genom-40943,
  year={2017},
  doi={10.1002/jez.b.22719},
  title={Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish},
  number={7},
  volume={328},
  issn={1552-5007},
  journal={Journal of experimental zoology part B : molecular and developmental evolution},
  pages={607--619},
  author={Symonová, Radka and Majtánová, Zuzana and Arias-Rodriguez, Lenin and Mořkovský, Libor and Kořínková, Tereza and Cavin, Lionel and Pokorná, Martina Johnson and Doležálková, Marie and Flajšhans, Martin and Meyer, Axel}
}
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