The role of MAPK signaling in patterning and establishing axial symmetry in the gastropod Haliotis asinina
The role of MAPK signaling in patterning and establishing axial symmetry in the gastropod Haliotis asinina
No Thumbnail Available
Files
There are no files associated with this item.
Date
2007
Authors
Editors
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Title in another language
Publication type
Journal article
Publication status
Published in
Developmental Biology ; 311 (2007), 1. - pp. 200-212. - ISSN 0012-1606. - eISSN 1095-564X
Abstract
Gastropods are members of the Spiralia, a diverse group of invertebrates that share a common early developmental program, which includes spiral cleavage and a larval trochophore stage. The spiral cleavage program results in the division of the embryo into four quadrants. Specification of the dorsal (D) quadrant is intimately linked with body plan organization and in equally cleaving gastropods occurs when one of the vegetal macromeres makes contact with overlying micromeres and receives an inductive signal that activates a MAPK signaling cascade. Following the induction of the 3D macromere, the embryo begins to gastrulate and assumes a bilateral cleavage pattern. Here we inhibit MAPK activation in 3D with U0126 and examine its effect on the formation and patterning of the trochophore, using a suite of territory-specific markers. The head (pretrochal) region appears to maintain quadri-radial symmetry in U0126-treated embryos, supporting a role for MAPK signaling in 3D in establishing dorsoventral polarity in this region. Posterior (posttrochal) structures – larval musculature, shell and foot – fail to develop in MAPK inhibited trochophores. Inhibition of 3D specification by an alternative method – monensin treatment – yields similar abnormal trochophores. However, genes that are normally expressed in the ectodermal structures (shell and foot) are detected in U0126- and monensin-perturbed larvae in patterns that suggest that this region has latent dorsoventral polarity that is manifested even in the absence of D quadrant specification.
Summary in another language
Subject (DDC)
570 Biosciences, Biology
Keywords
Gastropod,MAPK,Organizer,Mesoderm,Dorsoventral axis,D-quadrant,U0126 gastrulation
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690
KOOP, Demian, Gemma S. RICHARDS, Helen M. GUNTER, Bernard M. DEGNAN, 2007. The role of MAPK signaling in patterning and establishing axial symmetry in the gastropod Haliotis asinina. In: Developmental Biology. 311(1), pp. 200-212. ISSN 0012-1606. eISSN 1095-564X. Available under: doi: 10.1016/j.ydbio.2007.08.035BibTex
@article{Koop2007-11-01signa-17148, year={2007}, doi={10.1016/j.ydbio.2007.08.035}, title={The role of MAPK signaling in patterning and establishing axial symmetry in the gastropod Haliotis asinina}, number={1}, volume={311}, issn={0012-1606}, journal={Developmental Biology}, pages={200--212}, author={Koop, Demian and Richards, Gemma S. and Gunter, Helen M. and Degnan, Bernard M.} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/17148"> <dcterms:issued>2007-11-01</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/17148"/> <dc:rights>terms-of-use</dc:rights> <dcterms:bibliographicCitation>Publ. in: Developmental Biology ; 311 (2007), 1. - 200-212</dcterms:bibliographicCitation> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Degnan, Bernard M.</dc:contributor> <dc:creator>Gunter, Helen M.</dc:creator> <dc:creator>Koop, Demian</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/> <dc:contributor>Gunter, Helen M.</dc:contributor> <dcterms:abstract xml:lang="eng">Gastropods are members of the Spiralia, a diverse group of invertebrates that share a common early developmental program, which includes spiral cleavage and a larval trochophore stage. The spiral cleavage program results in the division of the embryo into four quadrants. Specification of the dorsal (D) quadrant is intimately linked with body plan organization and in equally cleaving gastropods occurs when one of the vegetal macromeres makes contact with overlying micromeres and receives an inductive signal that activates a MAPK signaling cascade. Following the induction of the 3D macromere, the embryo begins to gastrulate and assumes a bilateral cleavage pattern. Here we inhibit MAPK activation in 3D with U0126 and examine its effect on the formation and patterning of the trochophore, using a suite of territory-specific markers. The head (pretrochal) region appears to maintain quadri-radial symmetry in U0126-treated embryos, supporting a role for MAPK signaling in 3D in establishing dorsoventral polarity in this region. Posterior (posttrochal) structures – larval musculature, shell and foot – fail to develop in MAPK inhibited trochophores. Inhibition of 3D specification by an alternative method – monensin treatment – yields similar abnormal trochophores. However, genes that are normally expressed in the ectodermal structures (shell and foot) are detected in U0126- and monensin-perturbed larvae in patterns that suggest that this region has latent dorsoventral polarity that is manifested even in the absence of D quadrant specification.</dcterms:abstract> <dc:contributor>Richards, Gemma S.</dc:contributor> <dc:contributor>Koop, Demian</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-29T12:50:54Z</dc:date> <dc:language>eng</dc:language> <dc:creator>Richards, Gemma S.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-11-29T12:50:54Z</dcterms:available> <dcterms:title>The role of MAPK signaling in patterning and establishing axial symmetry in the gastropod Haliotis asinina</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:creator>Degnan, Bernard M.</dc:creator> </rdf:Description> </rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
No