Coarse-grained simulations of membranes under tension

Abstract

We investigate the properties of membranes under tension by Monte Carlo simulations of a generic coarse-grained model for lipid bilayers. We give a comprising overview of the behavior of several membrane characteristics, such as the area per lipid, the monolayer overlap, the nematic order, and pressure profiles. Both the low-temperature regime, where the membranes are in a gel Lβ′ phase, and the high-temperature regime, where they are in the fluid Lα phase, are considered. In the Lβ′ state, the membrane is hardly influenced by tension. In the fluid state, high tensions lead to structural changes in the membrane, which result in different compressibility regimes. The ripple state Pβ′, which is found at tension zero in the transition regime between Lα and Lβ′, disappears under tension and gives way to an interdigitated phase. We also study the membrane fluctuations in the fluid phase. In the low-tension regime the data can be fitted nicely to a suitably extended elastic theory. At higher tensions the elastic fit consistently underestimates the strength of long-wavelength fluctuations. Finally, we investigate the influence of tension on the effective interaction between simple transmembrane inclusions and show that tension can be used to tune the hydrophobic mismatch interaction between membrane proteins.