Neural signatures of semantic and phonemic fluency in young and old adults

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2009
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Meinzer, Marcus
Wilser, Lotte
Conway, Tim
Gonzalez-Rothi, Leslie
Crosson, Bruce
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Journal of Cognitive Neuroscience. 2009, 21(10), pp. 2007-2018. ISSN 0898-929X. eISSN 1530-8898. Available under: doi: 10.1162/jocn.2009.21219
Zusammenfassung

As we age, our ability to select and produce words changes, yet we know little about the underlying neural substrate of word-finding difficulties in old adults. The present study was designed to elucidate changes in specific frontally mediated retrieval processes involved in word-finding difficulties associated with advanced age. We implemented two overt verbal (semantic and phonemic) fluency tasks during functional magnetic resonance imaging and compared brain activity patterns of old and young adults. Performance during the phonemic task was comparable for both age-groups and mirrored by strongly left lateralized (frontal) activity patterns. On the other hand, a significant drop of performance during the semantic task in the older goup was accompanied by additional right (inferior and middle) frontal activity, which was negatively correlated with performance. Moreover, the younger group recruited different subportions of the left inferior frontal gyrus for both fluency tasks, while the older participants failed to show this distinction. Thus, functional integrity and efficient recruitment of left frontal language areas seems to be critical for successful word-retrieval in old age.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
400 Sprachwissenschaft, Linguistik
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aging, functional magnetic resonance imaging, higher level cognition, neuropsychology, prefrontal cortex
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ISO 690MEINZER, Marcus, Tobias FLAISCH, Lotte WILSER, Carsten EULITZ, Brigitte ROCKSTROH, Tim CONWAY, Leslie GONZALEZ-ROTHI, Bruce CROSSON, 2009. Neural signatures of semantic and phonemic fluency in young and old adults. In: Journal of Cognitive Neuroscience. 2009, 21(10), pp. 2007-2018. ISSN 0898-929X. eISSN 1530-8898. Available under: doi: 10.1162/jocn.2009.21219
BibTex
@article{Meinzer2009-10Neura-2724,
  year={2009},
  doi={10.1162/jocn.2009.21219},
  title={Neural signatures of semantic and phonemic fluency in young and old adults},
  number={10},
  volume={21},
  issn={0898-929X},
  journal={Journal of Cognitive Neuroscience},
  pages={2007--2018},
  author={Meinzer, Marcus and Flaisch, Tobias and Wilser, Lotte and Eulitz, Carsten and Rockstroh, Brigitte and Conway, Tim and Gonzalez-Rothi, Leslie and Crosson, Bruce}
}
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