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Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice

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2008

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Moheno, Phillip
DiPasquale, Antonio G.
Rheingold, Arnold L.
Fuchs, Dietmar

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https://doi.org/10.1016/j.ijpharm.2007.12.021
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International Journal of Pharmaceutics. Elsevier. 2008, 355(1-2), pp. 238-248. ISSN 0378-5173. eISSN 1873-3476. Available under: doi: 10.1016/j.ijpharm.2007.12.021

Zusammenfassung

In vivo studies of the effectiveness of various forms of calcium pterin reveal significant antitumor activity associated with (1:4, mol/mol) calcium pterin (CaPterin), (1:2, mol/mol) calcium pterin, dipterinyl calcium pentahydrate (DCP), as well as unexpectedly for a calcium chloride dihydrate solution in nude mice with MDA-MB-231 xenographs. Stepwise regression analysis of nine plasma cytokine and indoleamine 2,3-dioxygenase (IDO) metabolite levels identified four effects correlated to (1:4, mol/mol) calcium pterin administration: (1) decreased IL-6, (2) increased IL-10, (3) decreased IFN-γ, and (4) increased kynurenine. Conclusion: (1:4, mol/mol) CaPterin exerts significant (by Spearman rank order correlation) dose–response antitumor activity in nude mice with MDA-MB-231 xenographs, and sustains both inflammatory and anti-inflammatory changes in the levels of certain plasma factors.

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540 Chemie

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ISO 690MOHENO, Phillip, Wolfgang PFLEIDERER, Antonio G. DIPASQUALE, Arnold L. RHEINGOLD, Dietmar FUCHS, 2008. Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice. In: International Journal of Pharmaceutics. Elsevier. 2008, 355(1-2), pp. 238-248. ISSN 0378-5173. eISSN 1873-3476. Available under: doi: 10.1016/j.ijpharm.2007.12.021
BibTex
@article{Moheno2008-05-01Cytok-58606,
  year={2008},
  doi={10.1016/j.ijpharm.2007.12.021},
  title={Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice},
  number={1-2},
  volume={355},
  issn={0378-5173},
  journal={International Journal of Pharmaceutics},
  pages={238--248},
  author={Moheno, Phillip and Pfleiderer, Wolfgang and DiPasquale, Antonio G. and Rheingold, Arnold L. and Fuchs, Dietmar}
}
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