Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice

Moheno, Phillip; Pfleiderer, Wolfgang; DiPasquale, Antonio G.; Rheingold, Arnold L.; Fuchs, Dietmar

Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice

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Date

2008

Authors

Moheno, Phillip

Pfleiderer, Wolfgang

DiPasquale, Antonio G.

Rheingold, Arnold L.

Fuchs, Dietmar

DOI (citable link)

10.1016/j.ijpharm.2007.12.021

Collections

Chemie

Publication type

Journal article

Publication status

Published

Published in

International Journal of Pharmaceutics ; 355 (2008), 1-2. - pp. 238-248. - Elsevier. - ISSN 0378-5173. - eISSN 1873-3476

Abstract

In vivo studies of the effectiveness of various forms of calcium pterin reveal significant antitumor activity associated with (1:4, mol/mol) calcium pterin (CaPterin), (1:2, mol/mol) calcium pterin, dipterinyl calcium pentahydrate (DCP), as well as unexpectedly for a calcium chloride dihydrate solution in nude mice with MDA-MB-231 xenographs. Stepwise regression analysis of nine plasma cytokine and indoleamine 2,3-dioxygenase (IDO) metabolite levels identified four effects correlated to (1:4, mol/mol) calcium pterin administration: (1) decreased IL-6, (2) increased IL-10, (3) decreased IFN-γ, and (4) increased kynurenine. Conclusion: (1:4, mol/mol) CaPterin exerts significant (by Spearman rank order correlation) dose–response antitumor activity in nude mice with MDA-MB-231 xenographs, and sustains both inflammatory and anti-inflammatory changes in the levels of certain plasma factors.

Subject (DDC)

540 Chemistry

Cite This

ISO 690

MOHENO, Phillip, Wolfgang PFLEIDERER, Antonio G. DIPASQUALE, Arnold L. RHEINGOLD, Dietmar FUCHS, 2008. Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice. In: International Journal of Pharmaceutics. Elsevier. 355(1-2), pp. 238-248. ISSN 0378-5173. eISSN 1873-3476. Available under: doi: 10.1016/j.ijpharm.2007.12.021

BibTex

@article{Moheno2008-05-01Cytok-58606,
  year={2008},
  doi={10.1016/j.ijpharm.2007.12.021},
  title={Cytokine and IDO metabolite changes effected by calcium pterin during inhibition of MDA-MB-231 xenograph tumors in nude mice},
  number={1-2},
  volume={355},
  issn={0378-5173},
  journal={International Journal of Pharmaceutics},
  pages={238--248},
  author={Moheno, Phillip and Pfleiderer, Wolfgang and DiPasquale, Antonio G. and Rheingold, Arnold L. and Fuchs, Dietmar}
}

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Refereed

Yes